262例药品不良反应报告

目的：了解贵阳中医学院第一附属医院（以下简称＂我院＂）药品不良反应（adverse drug reaction,ADR）的发生特点及规律,促进临床合理用药。方法：对2016年上报的262例发生ADR患者的性别与年龄、引发ADR的药物类别与具体药品、给药途径、ADR分级、ADR累及器官和（或）系统及临床表现、ADR转归等进行统计分析。结果：262例发生ADR的患者中,女性194例（占26.34%）,男性68例（占73.66%）,女性明显多于男性;≥50岁者多发;共涉及药物15类、110个品种,抗感染药引发的ADR病例数最多（70例,占26.72%）,其次为中药制剂（45例,占17.18%）;注射...

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Published in中国医院用药评价与分析 Vol. 17; no. 7; pp. 979 - 981
Main Author 于佳 陈艳 李广松 王欣欣 华玉玲 张建玲
Format Journal Article
LanguageChinese
Published 贵阳中医学院第一附属医院药剂科,贵州 贵阳,550002 2017
Subjects
合理用药
用药安全
药品不良反应
合理用药
Rational drug application
Safe medication
药品不良反应
Adverse drug reactions
用药安全
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ISSN1672-2124
DOI10.14009/j.issn.1672-2124.2017.07.039

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Summary:目的：了解贵阳中医学院第一附属医院（以下简称＂我院＂）药品不良反应（adverse drug reaction,ADR）的发生特点及规律,促进临床合理用药。方法：对2016年上报的262例发生ADR患者的性别与年龄、引发ADR的药物类别与具体药品、给药途径、ADR分级、ADR累及器官和（或）系统及临床表现、ADR转归等进行统计分析。结果：262例发生ADR的患者中,女性194例（占26.34%）,男性68例（占73.66%）,女性明显多于男性;≥50岁者多发;共涉及药物15类、110个品种,抗感染药引发的ADR病例数最多（70例,占26.72%）,其次为中药制剂（45例,占17.18%）;注射用血栓通（冻干粉末）引发的ADR病例数居首位（20例,占7.63%）;静脉滴注给药引发的ADR病例数居首位,其次为口服给药。一般的ADR 235例,严重的ADR 27例,以皮肤及其附件损害最为常见,其次分别为胃肠系统、循环系统。经过积极对症处理,患者好转147例、治愈109例、未好转2例、不详4例,未见死亡病例。结论：ADR的发生与多种因素相关,临床应加强ADR的监测与上报工作,保障患者用药安全,促进临床合理用药。
Bibliography:OBJECTIVE： To investigate the characteristics and regularity of adverse drug reactions（ ADR） reported by the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine（ hereinafter referred to as ＂our hospital＂）,so as to promote rational drug application. METHODS： 262 reported cases of ADR in 2016 were collected and analyzed in terms of patients＇ genders,ages,species and specific names of ADR-inducing drugs,routes of administration,grade of ADR,ADR involved organs and（ or） systems and its clinical features,prognoses of ADR,etc. RESULTS： Of 262 cases,194 cases were female（ accounted for 26. 34%）,which was significantly more than male（ 68 cases,accounted for73. 66%）; mostly aged ≥60; 110 species of 15 kinds of drugs were involved,anti-infectious drug had induced the most ADR（ 70 cases,accounted for 26. 72%）,secondly was traditional Chinese medicine（ 45 cases,accounted for 17. 18%）;Xueshuantong injection（ freeze-dried powder） had induced the most ADR（ 20 cases,accounted for 7. 63%）. Intravenous
ISSN:1672-2124
DOI:10.14009/j.issn.1672-2124.2017.07.039