Arterial stiffness and ischemic stroke in subjects with and without metabolic syndrome

• Published in: Atherosclerosis Vol. 225; no. 1; pp. 216 - 219
• Main Authors: Tuttolomondo, Antonino, Di Raimondo, Domenico, Di Sciacca, Riccardo, Pecoraro, Rosaria, Arnao, Valentina, Buttà, Carmelo, Licata, Giuseppe, Pinto, Antonio
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.11.2012; Elsevier
• Subjects: Aged; Aged, 80 and over; Aix; albuminuria; Arterial stiffness; atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; blood glucose; body mass index; brain; Cardiology. Vascular system; Cardiovascular; complications; correlation; diabetes; etiology; Female; Humans; hypertension; infarction; low density lipoprotein cholesterol; Male; Medical sciences; metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - physiopathology; Middle Aged; Neurology; pathogenesis; patients; physiopathology; Pulse Wave Analysis; PVW; Stroke; Stroke - etiology; Stroke - physiopathology; systolic blood pressure; toasting; Vascular diseases and vascular malformations of the nervous system; Vascular Stiffness; PVW; Aix; Stroke; Arterial stiffness; Endocrinopathy; Human; Cerebral infarction; Nervous system diseases; Metabolic diseases; Cardiovascular disease; Metabolic syndrome; Cerebral disorder; Vascular disease; Central nervous system disease; Atherosclerosis; Brain ischemia; Stiffness; Cerebrovascular disease
• ISSN: 0021-9150; 1879-1484; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2012.08.027

We conducted a study to evaluate arterial stiffness markers in subjects with acute ischemic stroke and metabolic syndrome and in relation to TOAST subtype of stroke. We enrolled 130 patients with acute ischemic stroke and metabolic syndrome, 127 patients with acute ischemic stroke without metabolic syndrome and 120 control subjects without acute stroke. Applanation tonometry to record pulse wave velocity (PWV). Stroke patients with metabolic syndrome, compared control subjects without stroke showed higher PWV. In subjects with ischemic stroke and metabolic syndrome, PWV was more significantly and positively correlated with body mass index, systolic blood pressure, hypertension, diabetes, glucose blood levels, LDL cholesterol levels, total cholesterol levels, micro-albuminuria, carotid plaque, previous brain infarct at neuro-imaging. Our findings underline important role of both small vessel disease and atherosclerosis on arterial stiffness pathogenesis in the clinical setting of metabolic syndrome.