Malignant Gastrointestinal Stromal Tumor Originating in the Lesser Omentum, Complicated by Rapidly Progressive Glomerulonephritis and Gastric Carcinoma

• Published in: Internal Medicine Vol. 43; no. 2; pp. 102 - 105
• Main Authors: NAKAYA, Izaya, IWATA, Yasunori, ABE, Toshio, YOKOYAMA, Hitoshi, ODA, Yoshio, NOMURA, Gakuji
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 01.02.2004; Japanese Society of Internal Medicine
• Subjects: Acute Kidney Injury - etiology; acute renal failure; Adenocarcinoma - complications; Adenocarcinoma - diagnosis; Aged; and C-Kit; Biological and medical sciences; Disease Progression; double cancer; Fatal Outcome; Gastrointestinal Neoplasms - complications; Gastrointestinal Neoplasms - pathology; General aspects; Glomerulonephritis; Glomerulonephritis - complications; Humans; Male; Medical sciences; Neoplasms, Multiple Primary - complications; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Omentum; Peritoneal Neoplasms - complications; Peritoneal Neoplasms - pathology; Renal failure; Stomach Neoplasms - complications; Stomach Neoplasms - diagnosis; Stromal Cells - pathology; Kidney disease; Glomerulonephritis; double cancer; Urinary system disease; Acute; Omentum; Malignant tumor; Medicine; Progressive; acute renal failure; Gastrointestinal tumor; C-Onc gene; Renal failure; Digestive diseases; Intestinal disease; Complication; and C-Kit; Stromal tumor; Gastric disease
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.43.102

A 69-year-old man was admitted with a large elastic mass in the upper abdomen. Computed tomography revealed a massive tumor in contact with the liver and gastrointestinal endoscopy revealed a gastric adenocarcinoma. He developed acute renal failure with massive proteinuria and died with a marked enlargement of the tumor. Autopsy revealed a tumor located in the lesser omentum. The tumor was considered to be a Gastrointestinal Stromal Tumor (GIST) because it was positive for c-kit. In addition, crescent formations and immune complexes in glomeruli were observed. We report the first case of GIST complicated by rapidly progressive glomerulonephritis and gastric carcinoma.