Increased Tyrosine in the Brain and Serum of Mice by Orally Administering Dipeptide SY

We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with...

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Published inBioscience, biotechnology, and biochemistry Vol. 77; no. 4; pp. 847 - 849
Main Authors ESAKI, Kayoko, OHMORI, Taketo, MAEBUCHI, Motohiro, NAKAMORI, Toshihiro, OHSHIMA, Toshihisa, FURUYA, Shigeki
Format Journal Article
LanguageEnglish
Published England Japan Society for Bioscience, Biotechnology, and Agrochemistry 2013
Oxford University Press
Subjects
Administration, Oral
Animals
brain
Brain - drug effects
Brain - metabolism
Dietary Proteins - analysis
dipeptide
Dipeptides - administration & dosage
Dipeptides - pharmacology
Male
Mice
Phgdh
serine
tyrosine
Tyrosine - blood
Tyrosine - metabolism
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Summary:We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with the same intake dose, but did not significantly affect the L-Ser level when compared with L-Ser administration.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.120747