微小RNAs与多囊卵巢综合征发病机制的研究进展

微小RNA（micro RNAs,mi RNAs）参与基因转录后表达调控。多囊卵巢综合征（PCOS）为一种异质性疾病,其发病机制尚不明确。多种mi RNAs在PCOS患者血清、颗粒细胞以及卵泡液中表达异常,提示mi RNAs参与PCOS的病理过程。mi RNAs与多种卵巢甾体激素的合成与分泌关系密切;参与卵泡的发育和闭锁,从而影响PCOS患者的排卵过程;还在胰岛素抵抗中发挥重要作用。mi R-125b、mi R-483和mi R-320通过调控多种靶基因而影响多条信号通路。综述mi RNAs在PCOS发病机制中的作用,一些功能比较明确的mi RNAs有望成为PCOS疾病诊断和预后评估的生物学标...

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Bibliographic Details
Published in国际生殖健康计划生育杂志 Vol. 36; no. 1; pp. 66 - 69
Main Author 肖华 应小燕 许波群
Format Journal Article
LanguageChinese
Published 210011,南京医科大学第二附属医院妇产科 2017
Subjects
卵泡发育
多囊卵巢综合征
微RNAs
性腺甾类激素
胰岛素抗药性
多囊卵巢综合征
Polycystic ovary syndrome
胰岛素抗药性
性腺甾类激素
MicroRNAs
Insulin resistance
Follicular development
Gonadal steroid hormones
卵泡发育
微RNAs
Online AccessGet full text
ISSN1674-1889

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Summary:微小RNA（micro RNAs,mi RNAs）参与基因转录后表达调控。多囊卵巢综合征（PCOS）为一种异质性疾病,其发病机制尚不明确。多种mi RNAs在PCOS患者血清、颗粒细胞以及卵泡液中表达异常,提示mi RNAs参与PCOS的病理过程。mi RNAs与多种卵巢甾体激素的合成与分泌关系密切;参与卵泡的发育和闭锁,从而影响PCOS患者的排卵过程;还在胰岛素抵抗中发挥重要作用。mi R-125b、mi R-483和mi R-320通过调控多种靶基因而影响多条信号通路。综述mi RNAs在PCOS发病机制中的作用,一些功能比较明确的mi RNAs有望成为PCOS疾病诊断和预后评估的生物学标志物,为PCOS的治疗提供新思路。
Bibliography:XIAO Hua,YING Xiao-yan,XU Bo-qun（Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China）
Micro RNAs; Polycystic ovary syndrome; Gonadal steroid hormones; Follicular development; Insulin resistance
Micro RNAs（mi RNAs） participate in the regulation of gene expression at the post-transcriptional level. The pathogenesis of polycystic ovary syndrome（PCOS） as a heterogeneous disorder is not clear at present.Abnormal expressions of mi RNAs in serum, the follicular fluid and granulosa cells of PCOS patients suggested that mi RNAs could contribute to the pathogenesis of PCOS. Mi RNAs are closely related to the synthesis and secretion of steroid hormones. Mi RNAs were found to be involved in the development and atresia of follicles and thus affect the ovulation process in PCOS patients. Mi RNAs also play an important role in the insulin resistance of PCOS patients. Mi R-125 b, mi R-483 and mi R-320 affect multiple signaling pathways by regulating multip
ISSN:1674-1889