Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1)

• Published in: Atherosclerosis Vol. 216; no. 2; pp. 390 - 394
• Main Authors: Bielinski, Suzette J., Reiner, Alex P., Nickerson, Deborah, Carlson, Chris, Bailey, Kent R., Thyagarajan, Bharat, Lange, Leslie A., Boerwinkle, Eric A., Jacobs, David R., Gross, Myron D.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.06.2011; Elsevier
• Subjects: adhesion; Adult; Alleles; antioxidants; Antioxidants - metabolism; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - genetics; Biological and medical sciences; Blacks; blood; Blood and lymphatic vessels; calcium; Calcium - metabolism; Cardiology. Vascular system; Cardiovascular; Carotid Arteries; Carotid Arteries - pathology; Cell adhesion molecules; Cohort Studies; Coronary calcium; coronary vessels; Coronary Vessels - pathology; Cross-Sectional Studies; DNA; Female; Genetics; Haplotypes; Humans; Inflammation; Intercellular Adhesion Molecule-1; Intercellular Adhesion Molecule-1 - blood; Intercellular Adhesion Molecule-1 - genetics; linkage disequilibrium; longitudinal studies; Male; Medical sciences; metabolism; Middle Aged; Neurology; pathology; Polymorphism, Genetic; Polymorphism, Single Nucleotide; risk; single nucleotide polymorphism; structural genes; Vascular diseases and vascular malformations of the nervous system; Whites; young adults; Genetics; Inflammation; Coronary calcium; Atherosclerosis; Cell adhesion molecules; Vascular disease; Calcium; Intercellular adhesion molecule 1; Cell adhesion molecule; Cardiovascular disease; Inorganic element; Polymorphism
• ISSN: 0021-9150; 1879-1484; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2011.02.018

Polymorphisms within the ICAM1 structural gene have been shown to influence circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) but their relation to atherosclerosis has not been clearly established. We sought to determine whether ICAM1 SNPs are associated with circulating sICAM-1 concentration, coronary artery calcium (CAC), and common and internal carotid intima medial thickness (IMT). 3550 black and white Coronary Artery Risk Development in Young Adults (CARDIA) Study subjects who participated in the year 15 and/or 20 examinations and were part of the Young Adult Longitudinal Study of Antioxidants (YALTA) ancillary study were included in this analysis. In whites, rs5498 was significantly associated with sICAM-1 (p<0.001) and each G-allele of rs5498 was associated with 5% higher sICAM-1 concentration. In blacks, each C-allele of rs5490 was associated with 6% higher sICAM-1 level; this SNP was in strong linkage disequilibrium with rs5491, a functional variant. Subclinical measurements of atherosclerosis in either year 15 or year 20 were not significantly related to ICAM1 SNPs. In CARDIA, ICAM1 DNA segment variants were associated with sICAM-1 protein level including the novel finding that levels differ by the functional variant rs5491. However, ICAM1 SNPs were not strongly related to either IMT or CAC. Our findings in CARDIA suggest that ICAM1 variants are not major early contributors to subclinical atherosclerosis.