Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases

Panax ginseng is one of the most universally used herbal medicines in Asian and Western countries. Most of the biological activities of ginseng are derived from its main constituents, ginsenosides. Interestingly, a number of studies have reported that ginsenosides and their metabolites/derivatives—i...

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Published inJournal of ginseng research Vol. 41; no. 4; pp. 435 - 443
Main Authors Kim, Ji Hye, Yi, Young-Su, Kim, Mi-Yeon, Cho, Jae Youl
Format Journal Article
LanguageEnglish
Published Korea (South) Elsevier B.V 01.10.2017
고려인삼학회
Elsevier
Subjects
ginsenosides
inflammation
inflammatory diseases
Panax ginseng
Review
signaling
기타의약학
inflammatory diseases
ginsenosides
signaling
inflammation
Panax ginseng
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Summary:Panax ginseng is one of the most universally used herbal medicines in Asian and Western countries. Most of the biological activities of ginseng are derived from its main constituents, ginsenosides. Interestingly, a number of studies have reported that ginsenosides and their metabolites/derivatives—including ginsenoside (G)-Rb1, compound K, G-Rb2, G-Rd, G-Re, G-Rg1, G-Rg3, G-Rg5, G-Rh1, G-Rh2, and G-Rp1—exert anti-inflammatory activities in inflammatory responses by suppressing the production of proinflammatory cytokines and regulating the activities of inflammatory signaling pathways, such as nuclear factor-κB and activator protein-1. This review discusses recent studies regarding molecular mechanisms by which ginsenosides play critical roles in inflammatory responses and diseases, and provides evidence showing their potential to prevent and treat inflammatory diseases.
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J. H. Kim and Y.-S. Yi contributed equally to this work.
ISSN:1226-8453
2093-4947
DOI:10.1016/j.jgr.2016.08.004