LncRNA‐mediated posttranslational modifications and reprogramming of energy metabolism in cancer

• Published in: Cancer communications (London, England) Vol. 41; no. 2; pp. 109 - 120
• Main Authors: Tan, Yue‐Tao, Lin, Jin‐Fei, Li, Ting, Li, Jia‐Jun, Xu, Rui‐Hua, Ju, Huai‐Qiang
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.02.2021; John Wiley and Sons Inc; Wiley
• Subjects: Adenosine; Autophagy; cancer metabolism; Cell cycle; Colorectal cancer; Cyclin-dependent kinases; Dehydrogenases; Drug resistance; Energy; enzyme; Enzymes; Gallbladder; Gene expression; Glucose; Growth factors; Hypoxia; Kinases; Liver cancer; long noncoding RNA; Lung cancer; metabolic reprogramming; Metabolism; Metastasis; MicroRNAs; Phosphorylation; posttranslational modification; Proteins; Review; Reviews; cancer metabolism; enzyme; long noncoding RNA; posttranslational modification; metabolic reprogramming
• ISSN: 2523-3548; 2523-3548
• DOI: 10.1002/cac2.12108

Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors. It is well recognized that long noncoding RNAs (lncRNAs) regulate energy metabolism in cancer. However, lncRNA‐mediated posttranslational modifications and metabolic reprogramming are unclear at present. In this review, we summarized the current understanding of the interactions between the alterations in cancer‐associated energy metabolism and the lncRNA‐mediated posttranslational modifications of metabolic enzymes, transcription factors, and other proteins involved in metabolic pathways. In addition, we discuss the mechanisms through which these interactions contribute to tumor initiation and progression, and the key roles and clinical significance of functional lncRNAs. We believe that an in‐depth understanding of lncRNA‐mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy.