Magnetospinography visualizes electrophysiological activity in the cervical spinal cord

Diagnosis of nervous system disease is greatly aided by functional assessments and imaging techniques that localize neural activity abnormalities. Electrophysiological methods are helpful but often insufficient to locate neural lesions precisely. One proposed noninvasive alternative is magnetoneurog...

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Published inScientific reports Vol. 7; no. 1; pp. 2192 - 12
Main Authors Sumiya, Satoshi, Kawabata, Shigenori, Hoshino, Yuko, Adachi, Yoshiaki, Sekihara, Kensuke, Tomizawa, Shoji, Tomori, Masaki, Ishii, Senichi, Sakaki, Kyohei, Ukegawa, Dai, Ushio, Shuta, Watanabe, Taishi, Okawa, Atsushi
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 19.05.2017
Nature Publishing Group UK
Nature Portfolio
Subjects
Adult
Aged
Central nervous system diseases
Cervical Cord - diagnostic imaging
Cervical Cord - physiology
Electrophysiological Phenomena
Humans
Magnetic fields
Magnetic Resonance Imaging - methods
Male
Median nerve
Nervous system
Neuroimaging - methods
Spinal cord
Spinal Cord - diagnostic imaging
Spinal Cord - physiology
Thoracic Vertebrae
Thorax
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Summary:Diagnosis of nervous system disease is greatly aided by functional assessments and imaging techniques that localize neural activity abnormalities. Electrophysiological methods are helpful but often insufficient to locate neural lesions precisely. One proposed noninvasive alternative is magnetoneurography (MNG); we have developed MNG of the spinal cord (magnetospinography, MSG). Using a 120-channel superconducting quantum interference device biomagnetometer system in a magnetically shielded room, cervical spinal cord evoked magnetic fields (SCEFs) were recorded after stimulation of the lower thoracic cord in healthy subjects and a patient with cervical spondylotic myelopathy and after median nerve stimulation in healthy subjects. Electrophysiological activities in the spinal cord were reconstructed from SCEFs and visualized by a spatial filter, a recursive null-steering beamformer. Here, we show for the first time that MSG with high spatial and temporal resolution can be used to map electrophysiological activities in the cervical spinal cord and spinal nerve.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-02406-8