Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

• Published in: FEBS letters Vol. 589; no. 11; pp. 1257 - 1265
• Main Authors: Nakamura, Yoshihiro, Miyaki, Shigeru, Ishitobi, Hiroyuki, Matsuyama, Sho, Nakasa, Tomoyuki, Kamei, Naosuke, Akimoto, Takayuki, Higashi, Yukihito, Ochi, Mitsuo
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 08.05.2015
• Subjects: angiogenesis; Animals; Cell Line; cytokines; Exosome; Exosomes; Humans; Mesenchymal stem cell; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Mice; MicroRNA; MicroRNAs - biosynthesis; Muscle Development; Muscle, Skeletal - cytology; Muscle, Skeletal - physiology; muscles; Myoblasts, Skeletal - cytology; Myoblasts, Skeletal - metabolism; Regeneration; Regeneration - physiology; Skeletal muscle; stem cells; tissue repair; Mesenchymal stem cell; Regeneration; MicroRNA; Exosome; Skeletal muscle

•Mesenchymal stem cell exosomes promoted myogenesis and angiogenesis in vitro.•Mesenchymal stem cell exosomes accelerated muscle regeneration in a mouse injury model.•Mesenchymal stem cell exosomes had low concentrations of repair-related cytokines.•Many repair-related microRNAs were identified in m...