Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

•Mesenchymal stem cell exosomes promoted myogenesis and angiogenesis in vitro.•Mesenchymal stem cell exosomes accelerated muscle regeneration in a mouse injury model.•Mesenchymal stem cell exosomes had low concentrations of repair-related cytokines.•Many repair-related microRNAs were identified in m...

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Published in	FEBS letters Vol. 589; no. 11; pp. 1257 - 1265
Main Authors	Nakamura, Yoshihiro, Miyaki, Shigeru, Ishitobi, Hiroyuki, Matsuyama, Sho, Nakasa, Tomoyuki, Kamei, Naosuke, Akimoto, Takayuki, Higashi, Yukihito, Ochi, Mitsuo
Format	Journal Article
Language	English
Published	England Elsevier B.V 08.05.2015
Subjects	angiogenesis Animals Cell Line cytokines Exosome Exosomes Humans Mesenchymal stem cell Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice MicroRNA MicroRNAs - biosynthesis Muscle Development Muscle, Skeletal - cytology Muscle, Skeletal - physiology muscles Myoblasts, Skeletal - cytology Myoblasts, Skeletal - metabolism Regeneration Regeneration - physiology Skeletal muscle stem cells tissue repair Mesenchymal stem cell Regeneration MicroRNA Exosome Skeletal muscle
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Abstract	•Mesenchymal stem cell exosomes promoted myogenesis and angiogenesis in vitro.•Mesenchymal stem cell exosomes accelerated muscle regeneration in a mouse injury model.•Mesenchymal stem cell exosomes had low concentrations of repair-related cytokines.•Many repair-related microRNAs were identified in mesenchymal stem cell exosomes.•MicroRNA-494 in mesenchymal stem cell exosomes enhanced myogenesis and angiogenesis. Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.
AbstractList	Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494. •Mesenchymal stem cell exosomes promoted myogenesis and angiogenesis in vitro.•Mesenchymal stem cell exosomes accelerated muscle regeneration in a mouse injury model.•Mesenchymal stem cell exosomes had low concentrations of repair-related cytokines.•Many repair-related microRNAs were identified in mesenchymal stem cell exosomes.•MicroRNA-494 in mesenchymal stem cell exosomes enhanced myogenesis and angiogenesis. Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494. Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle‐repair‐related cytokines, a number of repair‐related miRNAs were identified. This study suggests that the MSC‐derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR‐494. Mesenchymal stem cell exosomes promoted myogenesis and angiogenesis in vitro. Mesenchymal stem cell exosomes accelerated muscle regeneration in a mouse injury model. Mesenchymal stem cell exosomes had low concentrations of repair‐related cytokines. Many repair‐related microRNAs were identified in mesenchymal stem cell exosomes. MicroRNA‐494 in mesenchymal stem cell exosomes enhanced myogenesis and angiogenesis.
Author	Matsuyama, Sho Nakamura, Yoshihiro Miyaki, Shigeru Ochi, Mitsuo Nakasa, Tomoyuki Kamei, Naosuke Akimoto, Takayuki Ishitobi, Hiroyuki Higashi, Yukihito
Author_xml	– sequence: 1 givenname: Yoshihiro orcidid: 0000-0002-7181-5739 surname: Nakamura fullname: Nakamura, Yoshihiro email: nakamurayoshihiro0419@gmail.com organization: Department of Orthopedic Surgery, Hiroshima University, Hiroshima, Japan – sequence: 2 givenname: Shigeru surname: Miyaki fullname: Miyaki, Shigeru organization: Department of Orthopedic Surgery, Hiroshima University, Hiroshima, Japan – sequence: 3 givenname: Hiroyuki surname: Ishitobi fullname: Ishitobi, Hiroyuki organization: Department of Regenerative Medicine, Hiroshima University Hospital, Hiroshima, Japan – sequence: 4 givenname: Sho surname: Matsuyama fullname: Matsuyama, Sho organization: Department of Orthopedic Surgery, Hiroshima University, Hiroshima, Japan – sequence: 5 givenname: Tomoyuki surname: Nakasa fullname: Nakasa, Tomoyuki organization: Department of Orthopedic Surgery, Hiroshima University, Hiroshima, Japan – sequence: 6 givenname: Naosuke surname: Kamei fullname: Kamei, Naosuke organization: Department of Orthopedic Surgery, Hiroshima University, Hiroshima, Japan – sequence: 7 givenname: Takayuki surname: Akimoto fullname: Akimoto, Takayuki organization: Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan – sequence: 8 givenname: Yukihito surname: Higashi fullname: Higashi, Yukihito organization: Department of Regenerative Medicine, Hiroshima University Hospital, Hiroshima, Japan – sequence: 9 givenname: Mitsuo surname: Ochi fullname: Ochi, Mitsuo organization: Department of Orthopedic Surgery, Hiroshima University, Hiroshima, Japan
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25862500$$D View this record in MEDLINE/PubMed
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Copyright	2015 Federation of European Biochemical Societies FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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Keywords	Mesenchymal stem cell Regeneration MicroRNA Exosome Skeletal muscle
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Notes	Y.N.: the conception and design of the study, acquisition of data, analysis and interpretation of data, manuscript writing; S.M.: the conception and design of the study, acquisition of data, analysis and interpretation of data, manuscript writing; H.I.: acquisition of data, analysis and interpretation of data; S.M.: acquisition of data; T.N.: analysis and interpretation of data; N.K.; analysis and interpretation of data; T.A.: acquisition of data, analysis and interpretation of data; Y.H.: analysis and interpretation of data; M.O.: final approval of the version to be submitted. Yoshihiro Nakamura and Shigeru Miyaki contributed equally to this work. Author contributions ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
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Snippet	•Mesenchymal stem cell exosomes promoted myogenesis and angiogenesis in vitro.•Mesenchymal stem cell exosomes accelerated muscle regeneration in a mouse injury... Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular...
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SubjectTerms	angiogenesis Animals Cell Line cytokines Exosome Exosomes Humans Mesenchymal stem cell Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice MicroRNA MicroRNAs - biosynthesis Muscle Development Muscle, Skeletal - cytology Muscle, Skeletal - physiology muscles Myoblasts, Skeletal - cytology Myoblasts, Skeletal - metabolism Regeneration Regeneration - physiology Skeletal muscle stem cells tissue repair
Title	Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration
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