1245-P: Heart Failure Biomarkers in Diabetes—A National Reference Laboratory Study
Background: Recent guidelines1,2 recommend yearly biomarker screening (BNP, NT-proBNP or hs-cardiac troponin) of patients with diabetes at-risk for heart failure (HF) and team-based care with a cardiovascular specialist if elevated1-3. Methods: Using de-identified laboratory results from Labcorp® pa...
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Published in | Diabetes (New York, N.Y.) Vol. 72; no. Supplement_1; p. 1 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
New York
American Diabetes Association
20.06.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Background: Recent guidelines1,2 recommend yearly biomarker screening (BNP, NT-proBNP or hs-cardiac troponin) of patients with diabetes at-risk for heart failure (HF) and team-based care with a cardiovascular specialist if elevated1-3.
Methods: Using de-identified laboratory results from Labcorp® patients (2015-2022), we studied diabetes and HF ICD incidence via HbA1c and subsequent BNP/NT-proBNP (in pg/mL). Patients were classified as A1c consistent with no diabetes, prediabetes, or diabetes and newly diagnosed HF if they had no HF-associated ICD on/before date of initial HF testing and assigned one on a later date. Distribution of HF by cohort was evaluated by chi squared and likelihood by odds ratios (OR).
Results: There were 805,512 unique patients with A1c and either BNP/NT-proBNP performed. Using published cutoffs1-3, new diagnosis of HF by ICD was significantly different among cohorts for all cutoffs (p<0.001) and more likely in patients with diabetes compared to those without (OR 1.48 by BNP ≥ 35, 1.45 by BNP ≥ 50, 1.37 by NT-proBNP). As BNP cutoff increased, patients meeting criteria decreased. NT-proBNP > 125 had similar proportional yield of HF diagnosis to BNP ≥ 35.
Conclusion: Patients with diabetes (by A1c) were more likely to have a new diagnosis of HF on subsequent testing than patients without diabetes. The BNP cutoff utilized has meaningful implications for the number of patients referred to team-based care.
Disclosure
D.Alfego: Employee; LabCorp. A.Valcour: Employee; LabCorp. Z.Shajani-yi: Employee; LabCorp. R.M.Young: Employee; LabCorp. R.M.Sullivan: Employee; LabCorp. |
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ISSN: | 0012-1797 1939-327X |
DOI: | 10.2337/db23-1245-P |