辐照对盐酸克伦特罗降解效应的初步研究

采用电子束辐照处理盐酸克伦特罗，应用液相色谱串联质谱、红外光谱等技术研究盐酸克伦特罗辐照降解规律及辐解产物的结构，分析辐照对盐酸克伦特罗的降解效应。实验结果表明，原始浓度为18mg·kg^-1和45mg·kg^-1的盐酸克伦特罗水溶液浓度随吸收剂量增加而降低，且在吸收剂量为5kGy和10kGy时降解率达到90％以上；在低剂量下（〈5kGy）盐酸克伦特罗分子的-OH和-Cl基团脱落，随着剂量的增加-OH，-NH2，卟iH-和-C（CH3）3等基团也发生了不同程度的改变或脱落，表明电子束辐照可有效降解盐酸克伦特罗。...

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Bibliographic Details
Published in辐射研究与辐射工艺学报 Vol. 32; no. 4; pp. 36 - 41
Main Author 顾可飞 陈志军 周昌艳 褚云霞 邓姗 李振兴
Format Journal Article
LanguageChinese
Published 上海市农业科学院农产品质量标准与检测技术研究所 上海201106 2014
农业部植物新品种测试(上海)分中心 上海201106%上海束能辐照技术有限公司 上海201106%上海市农业科学院农产品质量标准与检测技术研究所 上海201106%中国海洋大学食品科学与工程学院 青岛266003
Subjects
盐酸克伦特罗
红外光谱
质谱
辐照降解
盐酸克伦特罗
Infrared spectroscopy
Clenbuterol hydrochloride
辐照降解
红外光谱
质谱
Radiolysis
Mass spectrometry
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Summary:采用电子束辐照处理盐酸克伦特罗，应用液相色谱串联质谱、红外光谱等技术研究盐酸克伦特罗辐照降解规律及辐解产物的结构，分析辐照对盐酸克伦特罗的降解效应。实验结果表明，原始浓度为18mg·kg^-1和45mg·kg^-1的盐酸克伦特罗水溶液浓度随吸收剂量增加而降低，且在吸收剂量为5kGy和10kGy时降解率达到90％以上；在低剂量下（〈5kGy）盐酸克伦特罗分子的-OH和-Cl基团脱落，随着剂量的增加-OH，-NH2，卟iH-和-C（CH3）3等基团也发生了不同程度的改变或脱落，表明电子束辐照可有效降解盐酸克伦特罗。
Bibliography:Clenbuterol hydrochloride, Radiolysis, Mass spectrometry, Infrared spectroscopy
31-1258/TL
The degradation effect of electron beam irradiation on clenbuterol hydrochloride was investigated with the method of liquid chromatography-tandem mass spectrometry and infrared spectroscopy. Experimental results showed that the concentration of clenbuterol hydrochloride aqueous solution with original level of 18 ppm and 45ppm decreased with the increase of absorbed dose, and its degradation efficiency was higher than 90% at 5 kGy and 9 kGy respectively. The mass spectrometry showed that -OH and -C1 fell off at low absorbed dose. And with the increase of absorbed dose, the ions such as -NH2, -NH-, -C（CH3）3, -C1 were changed or lost. It indicates that electron beam irradiation could efficiently degrade clenbuterol hydrochloride.
GU Kefei CHEN Zhijun ZHOU Changyan CHU Yunxia DENG Shan LI Zhenxing 1（Institute for Agri-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China） 2（Sh
ISSN:1000-3436
DOI:10.11889/j.1000-3436.2014.rrj.32.040301