Molecular dissection of nuclear paraspeckles: towards understanding the emerging world of the RNP milieu

Paraspeckles are nuclear bodies built on an architectural long noncoding RNA, NEAT1, and a series of studies have revealed their molecular components, fine internal structures and cellular and physiological functions. Emerging lines of evidence suggest that paraspeckle formation is elicited by phase...

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Published inOpen biology Vol. 8; no. 10
Main Authors Nakagawa, Shinichi, Yamazaki, Tomohiro, Hirose, Tetsuro
Format Journal Article
LanguageEnglish
Published England The Royal Society 01.10.2018
Subjects
lncrna
neat1
nuclear bodies
paraspeckles
Review
super-resolution microscope
paraspeckles
nuclear bodies
super-resolution microscope
lncRNA
NEAT1
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Summary:Paraspeckles are nuclear bodies built on an architectural long noncoding RNA, NEAT1, and a series of studies have revealed their molecular components, fine internal structures and cellular and physiological functions. Emerging lines of evidence suggest that paraspeckle formation is elicited by phase separation of associating RNA-binding proteins containing intrinsically disordered regions, which induce ordered arrangement of paraspeckle components along NEAT1. In this review, we will summarize the history of paraspeckle research over the last couple of decades, especially focusing on the function and structure of the nuclear bodies. We also discuss the future directions of research on long noncoding RNAs that form 'RNP milieux', large and flexible phase-separated ribonucleoprotein complexes.
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ISSN:2046-2441
2046-2441
DOI:10.1098/rsob.180150