Paget’s disease of bone: a review of epidemiology, pathophysiology and management

Paget’s disease of bone is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. Fortunately, effective pharmacologic therapy, primarily with potent bisphosphonates, is now available to treat patients with co...

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Bibliographic Details
Published inTherapeutic Advances in Musculoskeletal Disease Vol. 1; no. 2; pp. 107 - 125
Main Author Shaker, Joseph L.
Format Book Review Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.12.2009
SAGE PUBLICATIONS, INC
Subjects
Bone diseases
Disease management
Epidemiology
Immunotherapy
Pathology
Review
bisphosphonates
Paget’s disease of bone
osteoclasts
Paget's disease of bone
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Summary:Paget’s disease of bone is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. Fortunately, effective pharmacologic therapy, primarily with potent bisphosphonates, is now available to treat patients with complications or symptoms. This review of Paget’s disease of bone will include epidemiology and pathophysiology, complications and clinical findings, indications for treatment, and the drugs currently available to treat this condition.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1759-720X
1759-7218
DOI:10.1177/1759720X09351779