Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines

• Published in: Journal of Veterinary Medical Science Vol. 64; no. 2; pp. 169 - 172
• Main Authors: Ohashi, E. (Tokyo Univ. (Japan)), Inoue, K, Kagechika, H, Hong, S.H, Nakagawa, T, Takahashi, T, Mochizuki, M, Nishimura, R, Sasaki, N
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.02.2002; Japan Science and Technology Agency
• Subjects: Animals; Apoptosis - drug effects; Benzazepines - pharmacology; Benzoates - pharmacology; canine melanoma; Cell Division - drug effects; Cell Line; Cell Transformation, Neoplastic - drug effects; DISEASE CONTROL; DOGS; Drug Synergism; In Situ Nick-End Labeling; MELANOMA; Melanoma - pathology; Retinoids - chemical synthesis; Retinoids - pharmacology; RETINOL; retionoid; Structure-Activity Relationship; Tumor Cells, Cultured
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.64.169

The effect of two natural retinoids and synthetic retinoids with or without retinoid synergists on the proliferation and differentiation of 3 melanoma cell lines were investigated in vitro. No retinoids showed significant growth inhibitory effect on these cell lines when used alone, however, cell differentiation and significant growth inhibition were observed when treated with a combination of retinoids and a retinoid synergist. This study may suggest that, though the cells showed low susceptibilities when retinoids were treated alone, the combination of retinoids and a retinoid synergist may be effective to control the growth of canine melanoma cell lines.