A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets

• Published in: Cancer letters Vol. 382; no. 2; pp. 203 - 214
• Main Authors: Jia, Dongyu, Liu, Zhenqiu, Deng, Nan, Tan, Tuan Zea, Huang, Ruby Yun-Ju, Taylor-Harding, Barbie, Cheon, Dong-Joo, Lawrenson, Kate, Wiedemeyer, Wolf R, Walts, Ann E, Karlan, Beth Y, Orsulic, Sandra
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 28.11.2016; Elsevier Limited
• Subjects: Actins - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; Cancer-associated fibroblasts; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Clinical outcomes; Coculture Techniques; Collagen; Collagen Type I - genetics; Collagen Type I - metabolism; Collagen Type I, alpha 1 Chain; Cytokines; Databases, Genetic; Disease-Free Survival; Drug resistance; Enzymes; Fibroblasts; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Genes; Growth factors; Hematology, Oncology and Palliative Medicine; Humans; Hybridization; Kaplan-Meier Estimate; Medical research; Metastasis; Mutation; Myofibroblasts; Myofibroblasts - metabolism; Myofibroblasts - pathology; Neoplasm Grading; Neoplasm Staging; Neoplasms, Glandular and Epithelial - genetics; Neoplasms, Glandular and Epithelial - metabolism; Neoplasms, Glandular and Epithelial - pathology; Neoplasms, Glandular and Epithelial - therapy; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Ovarian Neoplasms - therapy; Pan-cancer; Pancreatic cancer; Smooth muscle; Therapeutic targets; Time Factors; Toxicity; Transcriptome; Tumor Microenvironment; Womens health; α-smooth muscle actin; Pan-cancer; transforming growth factor β; TNC; fibroblast activation protein; podoplanin; Therapeutic targets; Cancer-associated fibroblasts; PDGFRα; palladin; CAFs; PDPN; PREdiction of Clinical Outcomes from Genomic Profiles; platelet-derived growth factor receptor α; PRECOG; epithelial–mesenchymal transition; Tumor microenvironment; tenascin-C; lysyl oxidase; EMT; chondroitin sulfate proteoglycan 4; ECM; LOX; FAP; PALLD; αSMA; TGFβ; CSPG4; Myofibroblasts; extracellular matrix
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2016.09.001

Highlights • COL11A1 is a highly specific biomarker of activated CAFs in multiple epithelial cancer types. • COL11A1 is not expressed in mesenchymal precursors or fibroblasts associated with non-cancerous conditions, such as inflammation and organ fibrosis. • Activated CAFs across genetically different epithelial cancer types express a highly conserved gene signature.