Clinical observations during induction and recovery of Xylazine-midazolam-propofol anesthesia in horses

• Published in: Journal of Veterinary Medical Science Vol. 65; no. 7; pp. 805 - 808
• Main Authors: Oku, K. (Japan Racing Association, Miho, Ibaraki. Miho Training Center), Yamanaka, T, Ashihara, N, Kawasaki, K, Mizuno, Y, Fujinaga, T
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.07.2003; Japan Science and Technology Agency
• Subjects: ANAESTHESIA; Anesthesia Recovery Period; Anesthesia, Intravenous - veterinary; Anesthetics, Intravenous - adverse effects; Anesthetics, Intravenous - pharmacology; Animals; Blood Pressure - drug effects; Drug Therapy, Combination; equine; HORSES; Hypoxia - chemically induced; intravenous anesthesia; Male; Midazolam - administration & dosage; Midazolam - adverse effects; Midazolam - pharmacology; Premedication; propofol; Propofol - administration & dosage; Propofol - adverse effects; Propofol - pharmacology; Time Factors; VETERINARY MEDICINE; XYLAZINE; Xylazine - administration & dosage; Xylazine - adverse effects; Xylazine - pharmacology
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.65.805

To evaluate clinical usefulness of xylazine (1.0 mg/kg)-midazolam (20 microg/kg)-propofol (3.0 mg/kg) anesthesia in horses, 6 adult Thoroughbred horses were examined. The quality of induction varied from poor to excellent and 5 out of 6 horses presented myotonus in the front half of the body. However, paddling immediately after induction observed in other reports of equine propofol anesthesia was not observed. Recovery time was 35.3 =+- 9.3 min and the quality of recovery was calm and smooth in all horses. Respiration rate decreased after induction and hypoxemia was observed during lateral recumbency. Heart rate also decreased after induction, however mean arterial blood pressure was maintained above approximately 100 mmHg.