The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors

• Published in: Journal of dermatological science Vol. 88; no. 1; pp. 117 - 125
• Main Authors: Chieosilapatham, Panjit, Niyonsaba, François, Kiatsurayanon, Chanisa, Okumura, Ko, Ikeda, Shigaku, Ogawa, Hideoki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2017
• Subjects: Antimicrobial (host defense) peptides; Antimicrobial Cationic Peptides - immunology; Antimicrobial Cationic Peptides - metabolism; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokines - metabolism; Cyclic AMP - metabolism; Dermatology; Humans; Insulin-Like Growth Factor Binding Protein 5 - immunology; Insulin-Like Growth Factor Binding Protein 5 - metabolism; Interleukin-8 - metabolism; Keratinocytes - immunology; Keratinocytes - metabolism; MAPK; MrgX receptor; NF-κB; Primary Cell Culture; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - immunology; Receptors, G-Protein-Coupled - metabolism; Regeneration - immunology; RNA Interference; RNA, Small Interfering - metabolism; Signal Transduction - immunology; Skin; Skin - cytology; Skin Physiological Phenomena - immunology; Up-Regulation; Vascular Endothelial Growth Factor A - metabolism; Wound healing; Wound Healing - immunology; host defense peptide; insulin-like growth factor-binding protein; MrgX receptor; IL; Wound healing; VEGF; human β-defensin; Antimicrobial (host defense) peptides; AMP-IBP5; antimicrobial peptide derived from insulin-like growth factor-binding protein 5; hBD; MAPK; IGFBP; NF-κB; MrgX; TGF; HDP; vascular endothelial growth factor; Skin; interleukin; transforming growth factor; Mas-related gene X
• ISSN: 0923-1811; 1873-569X
• DOI: 10.1016/j.jdermsci.2017.05.008

Highlights • We report that AMP-IBP5 stimulates various keratinocyte functions. • AMP-IBP5 activates keratinocytes through MrgX1-X4 receptors. • AMP-IBP5-induced activation is also via MAPK and NF-κB activation. • AMP-IBP5 will be a useful therapeutic agent for wound healing.