Surgical treatment outcomes of pulmonary inflammatory myofibroblastic tumors

• Published in: Annals of thoracic medicine Vol. 17; no. 1; pp. 44 - 50
• Main Authors: Demir, Ömer, Onal, Omer
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.01.2022; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Antimitotic agents; Antineoplastic agents; Lung cancer; lung neoplasm; Medical research; Medicine, Experimental; myofibroblastic tumor; Original; Patient outcomes; Patients; pulmonary inflammatory myofibroblastic tumor; Rankings; Rare diseases; Surgery; Surgical outcomes; surgical treatment; survival; Tumors; surgical treatment; pulmonary inflammatory myofibroblastic tumor; myofibroblastic tumor; Lung neoplasm; survival
• ISSN: 1817-1737; 1998-3557
• DOI: 10.4103/atm.atm_119_21

BACKGROUND: Pulmonary inflammatory myofibroblastic tumor (PIMT) is an extremely rare disease. The aim of this study was to share the surgical outcomes of these tumors. METHODS: Patients who were operated for pulmonary myofibroblastic tumors between January 2005 and January 2021 were determined by retrospectively scanning patient files. Patients' demographic characteristics, tumor location, surgical techniques, and other parameters were obtained from the patient files. The KaplanMeier method was used for survival calculations, whereas the log-rank test was used for comparison of survival calculations. RESULTS: PIMTs were noted in 14 patients (0.12%) in a total of 11,108 thoracic procedures performed in our institution between January 2005 and January 2021. The mean age of the patients was 28.2 (range: 2-67) years. Of the patients, six were male and eight were female, with 50% (n = 7) aged under 18 years. A total of 17 surgical procedures were performed on 14 patients. One patient underwent pneumonectomy, two patients lobectomy, ten0 patients wedge resection, and one patient underwent debulking surgery. A total of 11 patients had complete surgery, whereas three patients had incomplete surgery. The 10-year overall survival was 84.6% and the 10-year disease-free survival (DFS) was 75.0%. Complete resection was found to be the only and significant factor that had an effect on survival (P = 0.004) and DFS (P = 0.012). CONCLUSION: PIMTs are extremely rare. Complete surgery should be considered an effective factor in survival and DFS.