Virus-based nanoparticles as platform technologies for modern vaccines

Nanoscale engineering is revolutionizing the development of vaccines and immunotherapies. Viruses have played a key role in this field because they can function as prefabricated nanoscaffolds with unique properties that are easy to modify. Viruses are immunogenic via multiple pathways, and antigens...

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Bibliographic Details
Published inWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Vol. 8; no. 4; p. 554
Main Authors Lee, Karin L, Twyman, Richard M, Fiering, Steven, Steinmetz, Nicole F
Format Journal Article
LanguageEnglish
Published United States 01.07.2016
Subjects
Animals
Drug Delivery Systems - methods
Humans
Mice
Nanomedicine - methods
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Vaccination
Vaccines
Virion - chemistry
Virion - ultrastructure
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Summary:Nanoscale engineering is revolutionizing the development of vaccines and immunotherapies. Viruses have played a key role in this field because they can function as prefabricated nanoscaffolds with unique properties that are easy to modify. Viruses are immunogenic via multiple pathways, and antigens displayed naturally or by engineering on the surface can be used to create vaccines against the cognate virus, other pathogens, specific molecules or cellular targets such as tumors. This review focuses on the development of virus-based nanoparticle systems as vaccines indicated for the prevention or treatment of infectious diseases, chronic diseases, cancer, and addiction. WIREs Nanomed Nanobiotechnol 2016, 8:554-578. doi: 10.1002/wnan.1383 For further resources related to this article, please visit the WIREs website.
ISSN:1939-0041
DOI:10.1002/wnan.1383