法洛四联症患儿术前口服咪达唑仑、氯胺酮和右美托咪定的临床观察

目的·比较法洛四联症患儿术前口服咪达唑仑、氯胺酮和右美托咪定的临床有效性与安全性。方法·择期行法洛四联症纠治术的60例患儿随机分为3组，分别给予口服咪达唑仑（0.5mg/kg）、氯胺酮（5mg/kg）和右美托咪定（5μg/kg），每组20例。观察并记录给药接受度，给药前及给药后不同时间点的心率(HR)、脉搏血氧饱和度(SpO2)、镇静评分，用药30min后的分离评分及静脉置管评分。结果·右美托咪定组给药接受度显著高于咪达唑仑组和氯胺酮组（P<0.05），3组镇静起效时间的差异无统计学意义(P>0.05）。氯胺酮组的分离满意率和置管满意率显著高于咪达唑仑组和右美托咪定...

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Bibliographic Details
Published in上海交通大学学报（医学版） Vol. 37; no. 1; pp. 71 - 74
Main Author 李敏;王燕婷;张马忠;白洁;刘配配;孙瑛
Format Journal Article
LanguageChinese
Published 上海交通大学医学院附属上海儿童医学中心麻醉科,上海,200127 2017
Subjects
术前用药;咪达唑仑;氯胺酮;右美托咪定;法洛四联症
dexmedetomidine
氯胺酮
midazolam
ketamine
咪达唑仑
法洛四联症
右美托咪定
premedication
tetralogy of Fallot
术前用药
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Summary:目的·比较法洛四联症患儿术前口服咪达唑仑、氯胺酮和右美托咪定的临床有效性与安全性。方法·择期行法洛四联症纠治术的60例患儿随机分为3组，分别给予口服咪达唑仑（0.5mg/kg）、氯胺酮（5mg/kg）和右美托咪定（5μg/kg），每组20例。观察并记录给药接受度，给药前及给药后不同时间点的心率(HR)、脉搏血氧饱和度(SpO2)、镇静评分，用药30min后的分离评分及静脉置管评分。结果·右美托咪定组给药接受度显著高于咪达唑仑组和氯胺酮组（P<0.05），3组镇静起效时间的差异无统计学意义(P>0.05）。氯胺酮组的分离满意率和置管满意率显著高于咪达唑仑组和右美托咪定组（P<0.05）。与给药前基础值比较，3组患儿给药后各时点的HR、SpO2均无明显变化（P>0.05）。结论·术前口服咪达唑仑、氯胺酮和右美托咪定均可为法洛四联症患儿提供良好的镇静效果，口服氯胺酮患儿的分离满意率与置管满意率最高。
Bibliography:31-2045/R
premedication; midazolam; ketamine; dexmedetomidine; tetralogy of Fallot
Objective·To compare the efficacy and safety of oral premedication with midazolam(MID),ketamine(KET),and dexmedetomidine(DEX)in children with tetralogy of Fallot(TOF).Methods·Sixty children undergoing selective primary repair for TOF were randomly assigned to orallyreceiving MID(0.5mg/kg,Group M),KET(5mg/kg,Group K),and DEX(5μg/kg,Group D)with twenty children in each group.The acceptance ofadministration,HR,SpO2,and sedation score before administration and at different time points after administration,scores of separation and intravenouscannulation30min after administration were observed and recorded.Results·The acceptance of administration was significantly higher in Group D thanin other two groups(P<0.05).There was no significant difference in sedation onset time among three groups(P>0.05).The satisfaction rates of separationand intravenous cannulation were significantly higher in Group K than in Group D and Group M(P<
ISSN:1674-8115
DOI:10.3969/j.issn.1674-8115.2017.01.015