Spontaneous Remission of Thrombospondin Type-1 Domain-Containing-Associated Membranous Nephropathy

Membranous nephropathy often achieves spontaneous remission. However, there are scarce reports of spontaneous remission of thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy. A 64-year-old female presented with nephrotic syndrome and edema of the lower extremities....

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Published inInternal Medicine Vol. 60; no. 19; pp. 3125 - 3128
Main Authors Watanabe, Shiika, Suzuki, Tomo, Han, Wei, Nakata, Mayumi, Koitabashi, Kenichiro, Ichikawa, Daisuke, Kamijo-Ikemori, Atsuko, Koike, Junki, Shibagaki, Yugo
Format Journal Article
LanguageEnglish
Published Tokyo The Japanese Society of Internal Medicine 01.10.2021
Japan Science and Technology Agency
Subjects
Antibodies
Biopsy
Case Report
Edema
Immunofluorescence
Immunosuppressive agents
Internal medicine
Kidneys
Membranous nephropathy
Nephropathy
Nephrotic syndrome
Remission
spontaneous remission
Thrombospondin
THSD7A
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Summary:Membranous nephropathy often achieves spontaneous remission. However, there are scarce reports of spontaneous remission of thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy. A 64-year-old female presented with nephrotic syndrome and edema of the lower extremities. We diagnosed membranous nephropathy by kidney biopsy and confirmed positive THSD7A on immunofluorescence using frozen sections; serum THSD7A antibodies were also detected. Thirty-four months after the initial diagnosis, she achieved a spontaneous complete remission without immunosuppressive therapy. With the complete remission, no serum THSD7A levels were detected. In this study, we describe serial examinations of kidney biopsies and serum THSD7A antibodies.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
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Correspondence to Dr.　Tomo Suzuki, suzuki.tomo@kameda.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.6413-20