Intracoronary Injection of Mononuclear Bone Marrow Cells in Acute Myocardial Infarction

• Published in: The New England journal of medicine Vol. 355; no. 12; pp. 1199 - 1209
• Main Authors: Lunde, Ketil, Solheim, Svein, Aakhus, Svend, Arnesen, Harald, Abdelnoor, Michael, Egeland, Torstein, Endresen, Knut, Ilebekk, Arnfinn, Mangschau, Arild, Fjeld, Jan G, Smith, Hans Jørgen, Taraldsrud, Eli, Grøgaard, Haakon Kiil, Bjørnerheim, Reidar, Brekke, Magne, Müller, Carl, Hopp, Einar, Ragnarsson, Asgrimur, Brinchmann, Jan E, Forfang, Kolbjørn
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 21.09.2006
• Subjects: Biological and medical sciences; Bone marrow; Bone Marrow Transplantation - adverse effects; Bone Marrow Transplantation - methods; Cardiomyocytes; Coronary Vessels; Diagnostic Techniques, Cardiovascular; Female; General aspects; Heart attacks; Humans; Injections; Male; Medical imaging; Medical sciences; Middle Aged; Myocardial Infarction - physiopathology; Myocardial Infarction - therapy; NMR; Nuclear magnetic resonance; Stroke Volume; Transplantation, Autologous; Treatment Failure; Ventricular Function, Left; Medicine; Mononuclear cell; Acute; Coronary artery; Bone marrow; Injection; Myocyte
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa055706

To promote the regeneration of myocardial cells after myocardial infarction, intracoronary infusion of bone marrow cells, which contain stem cells and progenitor cells, has been investigated. In this study of patients with acute anterior myocardial infarction, infusion of bone marrow cells had no effect on left ventricular function or infarct size 6 months after the infarction. In this study of patients with acute anterior myocardial infarction, infusion of bone marrow cells had no effect on left ventricular function or infarct size 6 months after the infarction. Contrary to previous belief, there is evidence of regeneration of the myocardium throughout life, and the rate of this regeneration is increased after large myocardial infarctions. 1 However, regeneration seems to be limited to the viable myocardium and its border zone, 1 and the net loss of cardiomyocytes during myocardial infarction is a key factor in the resulting remodeling and in the impairment of cardiac-pump function. 2 , 3 The bone marrow harbors stem cells and progenitor cells that may be capable of solid-organ repair. 4 In experimental models of myocardial infarction, intramyocardial or intravenous injections of cells derived from bone marrow (BMC) have resulted . . .