CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis

• Published in: Journal of clinical pathology Vol. 55; no. 5; pp. 391 - 392
• Main Authors: Sumathi, V P, McCluggage, W G
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.05.2002; BMJ; BMJ Publishing Group Ltd; BMJ Publishing Group LTD; Copyright 2002 Journal of Clinical Pathology
• Subjects: Antigen-antibody reactions; Biological and medical sciences; Biomarkers - analysis; CD10; Cervix; Cicatrix - metabolism; Cysts; Diagnosis; Endometriosis; Endometriosis - diagnosis; Female; Female genital diseases; Female Urogenital Diseases - diagnosis; Genital system. Mammary gland; Gynecology. Andrology. Obstetrics; Humans; Immunohistochemistry; Immunohistochemistry - methods; Intestinal Diseases - diagnosis; Investigative techniques, diagnostic techniques (general aspects); Leukemia; Medical sciences; Methods; Neprilysin - analysis; Non tumoral diseases; Ovaries; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Peritoneal Diseases - diagnosis; Sarcoma; Short Reports; Stromal Cells - metabolism; Tumors; Uterus; United Kingdom; United Kingdom > UK; Human; Immunohistochemistry; Evaluation; Biological marker; Endometriosis; Female genital diseases; Sensitivity; Cohort study; Uterine diseases; Female; Stromal cell; Diagnosis; Ectopia
• ISSN: 0021-9746; 1472-4146
• DOI: 10.1136/jcp.55.5.391

Aims: Recent studies have shown that CD10 is a useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. The aim of this study was to investigate whether CD10 immunoreactivity is present in ectopic endometrial stroma and whether staining is of value in confirming a diagnosis of endometriosis. Methods/Results: Twenty five cases of endometriosis were stained with a commercially available antibody against CD10. Endometrial stromal cells were positive in 22 of 25 cases. There was little or no staining of other tissues. Conclusions: CD10 immunoreactivity is largely maintained in endometrial stromal cells located outside the uterus. Immunohistochemical staining with CD10 may be of value in confirming a diagnosis of endometriosis when there is morphological doubt.