HPV-associated head and neck cancer: a virus-related cancer epidemic

• Published in: The lancet oncology Vol. 11; no. 8; pp. 781 - 789
• Main Authors: Marur, Shanthi, Dr, D'Souza, Gypsyamber, PhD, Westra, William H, Prof, Forastiere, Arlene A, Prof
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2010; Elsevier Limited
• Subjects: Age; Alcohol; alcohols; Biology; Biomarkers, Tumor; Cancer therapies; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Carcinoma, Squamous Cell - virology; Chemotherapy; Epidemics; Epidemiology; Female; Head & neck cancer; Head and neck cancer; Hematology, Oncology and Palliative Medicine; Human papillomavirus; Human papillomavirus 16 - isolation & purification; Humans; Immunohistochemistry; In Situ Hybridization; Incidence; Infection; Infections; Male; Medical prognosis; Middle Aged; Mutation; Natural history; oropharyngeal cancer; Oropharyngeal Neoplasms - epidemiology; Oropharyngeal Neoplasms - pathology; Oropharyngeal Neoplasms - therapy; Oropharyngeal Neoplasms - virology; p53 protein; Papillomavirus Infections - complications; Papillomavirus Infections - virology; Polymerase Chain Reaction; Radiation; retinoblastoma; Retinoblastoma protein; Risk Factors; Sex Distribution; squamous cell carcinoma; Survival; Survival Rate; Tobacco; Tonsil; Tumor Virus Infections - complications; Tumor Virus Infections - virology; Tumors; Vaccines; White people; Women; United States > US; Sweden; Europe
• ISSN: 1470-2045; 1474-5488
• DOI: 10.1016/S1470-2045(10)70017-6

Summary A rise in incidence of oropharyngeal squamous cell cancer—specifically of the lingual and palatine tonsils—in white men younger than age 50 years who have no history of alcohol or tobacco use has been recorded over the past decade. This malignant disease is associated with human papillomavirus (HPV) 16 infection. The biology of HPV-positive oropharyngeal cancer is distinct with P53 degradation, retinoblastoma RB pathway inactivation, and P16 upregulation. By contrast, tobacco-related oropharyngeal cancer is characterised by TP53 mutation and downregulation of CDKN2A (encoding P16). The best method to detect virus in tumour is controversial, and both in-situ hybridisation and PCR are commonly used; P16 immunohistochemistry could serve as a potential surrogate marker. HPV-positive oropharyngeal cancer seems to be more responsive to chemotherapy and radiation than HPV-negative disease. HPV 16 is a prognostic marker for enhanced overall and disease-free survival, but its use as a predictive marker has not yet been proven. Many questions about the natural history of oral HPV infection remain under investigation. For example, why does the increase in HPV-related oropharyngeal cancer dominate in men? What is the potential of HPV vaccines for primary prevention? Could an accurate method to detect HPV in tumour be developed? Which treatment strategies reduce toxic effects without compromising survival? Our aim with this review is to highlight current understanding of the epidemiology, biology, detection, and management of HPV-related oropharyngeal head and neck squamous cell carcinoma, and to describe unresolved issues.