Biogenesis of secretory granules Implications arising from the immature secretory granule in the regulated pathway of secretion
In endocrine cells the regulated secretion of hormones, peptides, enzymes and neurotransmitters into the external medium occurs when mature secretory granules fuse with the plasma membrane. Secretory granules form at the trans-Golgi network (TGN) by envelopment of the dense-core aggregate of regulat...
Saved in:
Published in | FEBS Letters Vol. 285; no. 2; pp. 220 - 224 |
---|---|
Main Author | |
Format | Book Review Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
22.07.1991
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | In endocrine cells the regulated secretion of hormones, peptides, enzymes and neurotransmitters into the external medium occurs when mature secretory granules fuse with the plasma membrane. Secretory granules form at the trans-Golgi network (TGN) by envelopment of the dense-core aggregate of regulated secretory proteins by a specific membrane. The secretory granules initially formed at the TGN, referred to here as immature secretory granules, are morphologically and biochemically distinct from mature secretory granules. The functional similarities and differences between the immature secretory granule and the mature secretory granule, and the events involved in the maturation of the secretory granules are briefly discussed. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0014-5793 1873-3468 |
DOI: | 10.1016/0014-5793(91)80805-D |