Umbilical cord mesenchymal stem cells for COVID‐19 acute respiratory distress syndrome: A double‐blind, phase 1/2a, randomized controlled trial

• Published in: Stem cells translational medicine Vol. 10; no. 5; pp. 660 - 673
• Main Authors: Lanzoni, Giacomo, Linetsky, Elina, Correa, Diego, Messinger Cayetano, Shari, Alvarez, Roger A., Kouroupis, Dimitrios, Alvarez Gil, Ana, Poggioli, Raffaella, Ruiz, Phillip, Marttos, Antonio C., Hirani, Khemraj, Bell, Crystal A., Kusack, Halina, Rafkin, Lisa, Baidal, David, Pastewski, Andrew, Gawri, Kunal, Leñero, Clarissa, Mantero, Alejandro M. A., Metalonis, Sarah W., Wang, Xiaojing, Roque, Luis, Masters, Burlett, Kenyon, Norma S., Ginzburg, Enrique, Xu, Xiumin, Tan, Jianming, Caplan, Arnold I., Glassberg, Marilyn K., Alejandro, Rodolfo, Ricordi, Camillo
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2021; Oxford University Press
• Subjects: Acute respiratory distress syndrome; Adverse events; Anti-Inflammatory Agents - therapeutic use; Care and treatment; cell transplantation; cellular therapy; Chemokines; Clinical outcomes; Clinical trials; Coronaviruses; COVID-19; COVID-19 - therapy; Cytokine storm; Cytokines; Cytokines - blood; Design; Disease; Double-Blind Method; Double-blind studies; Ethylenediaminetetraacetic acid; Female; Growth factors; Hospitalization; Human Clinical; Humans; Immunomodulation; Inflammation; Intravenous administration; Laboratories; Male; Manufacturing; Mesenchymal Stem Cell Transplantation - adverse effects; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stem Cells; Middle Aged; Mortality; Patients; Plasma; Respiratory distress syndrome; respiratory tract; SARS-CoV-2 - drug effects; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Stem cells; transplantation; Treatment Outcome; Tumor necrosis factor-TNF; Umbilical cord; Umbilical Cord - cytology; United Kingdom; cell transplantation; mesenchymal stem cells; respiratory tract; transplantation; clinical trials; cellular therapy; umbilical cord

Acute respiratory distress syndrome (ARDS) in COVID‐19 is associated with high mortality. Mesenchymal stem cells are known to exert immunomodulatory and anti‐inflammatory effects and could yield beneficial effects in COVID‐19 ARDS. The objective of this study was to determine safety and explore effi...