Cytokine profile of the blood in mice with normal and abnormal heart rhythm

• Published in: Bulletin of experimental biology and medicine Vol. 152; no. 6; pp. 692 - 695
• Main Authors: Stenina, M. A., Krivov, L. I., Voevodin, D. A., Savchuk, V. I., Kovalchuk, L. V., Yarygin, V. N.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.04.2012; Springer; Springer Nature B.V
• Subjects: Animals; Arrhythmia; Biomedical and Life Sciences; Biomedicine; Blood levels; Bradycardia - blood; Bradycardia - immunology; Bradycardia - physiopathology; Cell Biology; Cytokines; Cytokines - blood; Cytokines - immunology; Data processing; Dystrophin; Dystrophin - genetics; Electrocardiography; Female; Granulocyte-macrophage colony-stimulating factor; Heart; Heart beat; Heart Rate - immunology; Heart Rate - physiology; Inflammation; Interleukin 1; Interleukin 10; Interleukin 17; Interleukin 2; Interleukin 4; Interleukin 5; Interleukin 6; Internal Medicine; Laboratory Medicine; Life span; Longevity; Macrophage colony stimulating factor; Male; Mice; Mice, Knockout; Mutation; Pathology; Rhythms; Tumor necrosis factor- alpha; Utrophin; Veins; mdx albino mice; cytokines; bradyarrhythmia; heart rhythm
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1608-9

Differences in the pools of 10 cytokine were found in blood samples from the caudal vein of mice with normal and abnormal heart rhythm. Both groups were albino mice bred by us and differing from mdx albino mice by the absence of mutation in muscular dystrophin gene. Mice with normal heart rhythm had low IL-17 content and elevated concentrations of proinflammatory cytokines IL-6 and IL-1α in comparison with the normal (according to published data). In mice with bradyarrhythmias, increased blood levels of IL-10, IL-6, IL-5, IL-2, IL-1α, IL-17, IL-4, TNF-α, and granulocyte-macrophage colony-stimulating factor were detected. The relative content of IL-4 and IL-17 in the total cytokine pool increased. The lifespan of mice with bradyarrhythmias and cytokine hyperexpression was shorter by 2-3 months in comparison with mice without heart rhythm disturbances and moderate changes in the cytokine pool.