In response to the letter “[11C]raclopride and extrastriatal binding to D2/3 receptors”

[...]Dr. Backes proposes that our findings of low or non-existing dopamine D2/3-receptor (D2/3R) occupancy of quetiapine in extrastriatal regions could be explained by a putative presence of specific [11C]raclopride binding in cerebellar grey matter, i.e. the reference region in our analysis. A more...

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Published inNeuroImage (Orlando, Fla.) Vol. 207; p. 116371
Main Authors Svensson, Jonas E., Schain, Martin, Plavén-Sigray, Pontus, Cervenka, Simon, Tiger, Mikael, Nord, Magdalena, Halldin, Christer, Farde, Lars, Lundberg, Johan
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.02.2020
Elsevier Limited
Elsevier
Subjects
Brain
Cerebellum
Dopamine D2 receptors
Medicin och hälsovetenskap
Neostriatum
Quetiapine
Raclopride
Substantia grisea
Thalamus
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Summary:[...]Dr. Backes proposes that our findings of low or non-existing dopamine D2/3-receptor (D2/3R) occupancy of quetiapine in extrastriatal regions could be explained by a putative presence of specific [11C]raclopride binding in cerebellar grey matter, i.e. the reference region in our analysis. A more suitable cross-validation would be in the setting of a within subject design. [...]as we show in our article, even for a region with “medium binding” such as thalamus, a large sample size (N = 350) would be needed for an appropriately powered examination of a 10% between-group difference in [11C]raclopride BPND. [...]we stay with our overall conclusion that caution must be exercised when interpreting results from reference tissue based quantification of [11C]raclopride binding outside of the striatum.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2019.116371