Changes in the Levels of N-Cadherin and PCNA in Skin Melanoma Cells Are Mediated through Matrix Metalloproteinase 9

Immunohistochemical studies revealed increased level of matrix metalloproteinase 9 in skin melanoma cells. Inhibition of matrix metalloproteinase 9 with interfering RNA changed the level of PCNA and reduced N-cadherin content in melanoma cells. This attests to the involvement of matrix metalloprotei...

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Published inBulletin of experimental biology and medicine Vol. 153; no. 3; pp. 364 - 366
Main Authors Aksenenko, M. B., Gyrylova, S. N., Ruksha, T. G.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.07.2012
Springer
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cadherins - genetics
Cadherins - metabolism
Cell Biology
Cell Line, Tumor
Humans
Internal Medicine
Laboratory Medicine
Matrix Metalloproteinase 9 - genetics
Matrix Metalloproteinase 9 - metabolism
Melanoma
Melanoma - genetics
Melanoma - metabolism
Pathology
Proliferating Cell Nuclear Antigen - genetics
Proliferating Cell Nuclear Antigen - metabolism
RNA
Skin
Skin Neoplasms - genetics
Skin Neoplasms - metabolism
Stomach cancer
skin melanoma
N-cadherin
matrix metalloproteinase 9
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Summary:Immunohistochemical studies revealed increased level of matrix metalloproteinase 9 in skin melanoma cells. Inhibition of matrix metalloproteinase 9 with interfering RNA changed the level of PCNA and reduced N-cadherin content in melanoma cells. This attests to the involvement of matrix metalloproteinase 9 in the realization of invasion and metastatic growth and in the regulation of tumor growth and progress.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1717-5