Porous 3D Prussian blue/cellulose aerogel as a decorporation agent for removal of ingested cesium from the gastrointestinal tract

• Published in: Scientific reports Vol. 8; no. 1; pp. 4540 - 14
• Main Authors: Lee, Ilsong, Kim, Sung-Hyun, Rethinasabapathy, Muruganantham, Haldorai, Yuvaraj, Lee, Go-Woon, Choe, Sang Rak, Jang, Sung-Chan, Kang, Sung-Min, Han, Young-Kyu, Roh, Changhyun, Cho, Wan-Seob, Huh, Yun Suk
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.03.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 140/146; 639/166/898; 639/166/985; 704/172/169/896; Adsorption; Cellulose; Cesium; Cytotoxicity; Epithelial cells; Gastrointestinal tract; Humanities and Social Sciences; Intestine; Macrophages; multidisciplinary; Oral administration; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-22715-w

In the present study, we successfully synthesized a porous three-dimensional Prussian blue-cellulose aerogel (PB-CA) composite and used it as a decorporation agent for the selective removal of ingested cesium ions (Cs + ) from the gastrointestinal (GI) tract. The safety of the PB-CA composite was evaluated through an in vitro cytotoxicity study using macrophage-like THP-1 cells and Caco-2 intestinal epithelial cells. The results revealed that the PB-CA composite was not cytotoxic. An adsorption study to examine the efficiency of the decorporation agent was conducted using a simulated intestinal fluid (SIF). The adsorption isotherm was fitted to the Langmuir model with a maximum Cs + adsorption capacity of 13.70 mg/g in SIF that followed pseudo-second-order kinetics. The PB-CA composite showed excellent stability in SIF with a maximum Cs + removal efficiency of 99.43%. The promising safety toxicology profile, remarkable Cs + adsorption efficacy, and excellent stability of the composite demonstrated its great potential for use as an orally administered drug for the decorporation of Cs + from the GI tract.