A NEW ANTIFUNGAL ANTIBIOTIC, CYSTARGIN: FERMENTATION, ISOLATION, AND CHARACTERIZATION

• Published in: Journal of antibiotics Vol. 41; no. 12; pp. 1763 - 1768
• Main Authors: URAMOTO, MASAKAZU, ITOH, YUMIKO, SEKIGUCHI, RITSUKO, SHIN-YA, KAZUO, KUSAKABE, HIROO, ISONO, KIYOSHI
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1988; Japan Antibiotics Research Association
• Subjects: 1,3- beta -glucan synthase; Actinomycetales - metabolism; Anti-Bacterial Agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; antifungal agents; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Biological and medical sciences; Biotechnology; cystargin; Fermentation; Fundamental and applied biological sciences. Psychology; Health. Pharmaceutical industry; Industrial applications and implications. Economical aspects; Kitasatosporia cystarginea; Medical sciences; Miscellaneous. Antibiotics with multiple activities; peptide antibiotics; Peptides - isolation & purification; Pharmacology. Drug treatments; Production of active biomolecules; Saccharomyces cerevisiae; Characterization; Antibiotic; Antifungal agent; Peptides; Production; Isolation; Fermentation; Biological activity; Physicochemical properties
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.41.1763

A new sulfur-containing peptide antifungal antibiotic, cystargin, was isolated from the fermentation broth of a new species of genus Kitasatosporia, designated as Kitasatosporia cystarginea. On acid hydrolysis, cystargin (C60H77N19O17S6) gave equimolar glycine, proline, aspartic acid and arginine. By performic acid oxidation, cysteic acid was detected after hydrolysis. It showed a growth inhibitory activity against various phytopathogenic fungi and inhibition of β-1, 3-glucan synthetase from Saccharomyces cerevisiae.