Use of Lactobacillus casei rhamnosus to Prevent Cholangitis in Biliary Atresia After Kasai Operation

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 60; no. 5; pp. 654 - 658
• Main Authors: Lien, Tien‐Hau, Bu, Ling‐Nan, Wu, Jia‐Feng, Chen, Huey‐Ling, Chen, An‐Chyi, Lai, Ming‐Wei, Shih, Hsiang‐Hung, Lee, I‐Hsien, Hsu, Hong‐Yuan, Ni, Yen‐Hsuan, Chang, Mei‐Hwei
• Format: Journal Article
• Language: English
• Published: United States by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology 01.05.2015
• Subjects: Anti-Bacterial Agents - therapeutic use; biliary atresia; Biliary Atresia - surgery; Body Weight; cholangitis; Cholangitis - etiology; Cholangitis - prevention & control; Disease-Free Survival; Escherichia coli - isolation & purification; Feces - microbiology; Female; Humans; Infant; Infant, Newborn; lactobacillus; Lactobacillus - isolation & purification; Lactobacillus casei; Lactobacillus rhamnosus; Male; Neomycin - therapeutic use; Pilot Projects; Portoenterostomy, Hepatic - adverse effects; Probiotics - therapeutic use; prophylaxis; Recurrence
• ISSN: 0277-2116; 1536-4801
• DOI: 10.1097/MPG.0000000000000676

ABSTRACT Objectives: Recurrent cholangitis may aggravate cholestatic liver cirrhosis in biliary atresia (BA) after the Kasai operation. This pilot study aimed to investigate whether Lactobacillus casei rhamnosus has the prophylactic efficacy for recurrent cholangitis in comparison with the conventional neomycin prophylaxis. Methods: Twenty jaundice‐free patients with BA ages 0 to 3 years who underwent a Kasai operation were enrolled and randomized into 2 groups with 10 patients each: neomycin (25 mg · kg−1 · day−1 for 4 days/wk) and L casei rhamnosus (8 × 108 colony‐forming unit per day) groups. The treatment duration was 6 months. Bacterial stool cultures were performed before treatment and 1, 3, and 6 months after starting treatment. In addition, 10 patients with BA with similar status but without prophylaxis served as the historical control group. Results: In the Lactobacillus group, 2 patients (20%, mean 0.03 ± 0.07 episodes per month) developed cholangitis during the study period, with the same frequency as in the neomycin group and significantly lower than that in the control group (80%, P = 0.005, mean 0.22 ± 0.16 episodes per month). The mean change in body weight z score during the 6 months in the Lactobacillus group was 0.97 ± 0.59, which was significantly better than that in the control group (−0.01 ± 0.79, P = 0.006). In bacterial stool cultures, the Lactobacillus and Escherichia coli populations significantly increased and decreased, respectively, in the Lactobacillus group. Conclusions: The use of L casei rhamnosus was as effective as neomycin in preventing cholangitis in patients with BA who underwent Kasai operation, and therefore could be considered as a potential alternative prophylactic regimen.