Study protocol: Early neurological deterioration in patients with minor stroke, frequency, predictors, and outcomes in Vietnam single-centre study

• Published in: PloS one Vol. 19; no. 5; p. e0302822
• Main Authors: Nguyen, Dung Tien, Mai, Ton Duy, Dao, Phuong Viet, Ha, Hung Tran, Le, Anh Tuan, Nguyen, Tuyet Trinh Thi, Vuong, Trung Xuan, Tran, Minh Cong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.05.2024; Public Library of Science (PLoS)
• Subjects: Aged; Brain research; Care and treatment; Case-Control Studies; Clinical outcomes; Complications and side effects; Degeneration; Development and progression; Female; Follow-Up Studies; Hospitalization; Humans; Ischemia; Longitudinal Studies; Male; Medical research; Medicine and Health Sciences; Medicine, Experimental; Middle Aged; Nervous system; Normal distribution; Observational studies; Patient outcomes; Patients; People and Places; Population; Prognosis; Regression analysis; Risk Factors; Severity of Illness Index; Stroke; Stroke (Disease); Stroke - epidemiology; Study Protocol; Traumatic brain injury; Vietnam - epidemiology; Vietnam
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0302822

Early neurological deterioration (END) is progressive neurological deterioration with an increase in NIHSS score of 2 points or more in the first 72 hours from the onset of acute ischemic stroke. END increases the risk of poor clinical outcomes at day 90 of ischemic stroke. We will study the frequency, predictors, and outcomes of patients with END in a case-control study at a comprehensive stroke centre in Vietnam. of the design is a descriptive observational study, longitudinal follow-up of patients with minor stroke hospitalized at the Stroke Center of Bach Mai Hospital from December 1, 2023, to December 1, 2024. Minor stroke patients characterized by NIHSS score ≤ 5 hospitalized within 24 hours of symptom onset will be recruited. The estimated END rate is about 30%, relative accuracy ε = 0.11, 95% reliability, expected 5% of patients lost data or follow-up, and an estimated sample size of 779 patients. This study will help determine the END rate in patients with minor stroke and related factors, thereby building a prognostic model for END. Our study determined the END rate in patients with minor stroke in Vietnam and also proposed risk factors for minor stroke management and treatment.