Application of concentrated growth factor in mandibular third molar extraction: A protocol for systematic review and meta-analysis

• Published in: PloS one Vol. 19; no. 5; p. e0302581
• Main Authors: Zhang, Hengxiao, Dong, Jianyong, Wang, Xiaoliang, Sun, Xiaodong, Wang, Jin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.05.2024; Public Library of Science (PLoS)
• Subjects: Analysis; Bias; Biology and Life Sciences; Clinical outcomes; Complications; Data analysis; Extraction; Growth factors; Human subjects; Humans; Intercellular Signaling Peptides and Proteins - administration & dosage; Intercellular Signaling Peptides and Proteins - pharmacology; Mandible; Mandible - surgery; Medicine and Health Sciences; Meta-analysis; Meta-Analysis as Topic; Molar, Third - surgery; Pain; Postoperative; Postoperative Complications - prevention & control; Randomized Controlled Trials as Topic; Registered Report Protocol; Research and Analysis Methods; Risk assessment; Sensitivity analysis; Software; Surgery; Systematic review; Systematic Reviews as Topic; Teeth; Temporomandibular joint; Tissue engineering; Tooth Extraction - methods; Wound healing; Wound Healing - drug effects; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0302581

We will perform the systematic review to evaluate the effect of applying concentrated growth factor (CGF) on relieving postoperative complications and promoting wound healing following mandibular third molar extraction. The PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, China Biology Medicine Disc (CBM), and VIP Databases will be comprehensively searched up to May 31, 2024. Randomized controlled trials (RCTs) examining the application of CGF after mandibular third molar extraction will be included. The protocol was registered in PROSPERO, and the registration ID was CRD42023463234. Two reviewers will conduct the literature search, eligible study selection, data extraction, and bias risk assessment (using the Cochrane Risk of Bias 2.0 tool). Data analysis will be performed with RevMan software (version 5.4). The results of this study will be available in a peer-reviewed journal. Our study will provide scientific evidence regarding the efficacy of applying CGF in mandibular third molar extraction.