Antipsychotics and OCD: Boon or Bane?

AAPs are a common augmentative strategy in treatment-resistant OCD. [...]some have contended that dopamine blockade is critical to facilitate 5-hydroxytryptamine (5HT) transmission in the cortico-striato-pallido-thalamo-cortical neurocircuitry in OCD. [3] have found an incidence of 12% of AAPs-induc...

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Published inIndian journal of psychological medicine Vol. 39; no. 6; pp. 830 - 831
Main Author Naguy, Ahmed
Format Journal Article
LanguageEnglish
Published New Delhi, India SAGE Publications 01.11.2017
Sage Publications Ltd. (UK)
Sage Publications, New Delhi India
Medknow Publications & Media Pvt Ltd
SAGE Publishing
Subjects
Antidepressants
Antipsychotic agents
Antipsychotics
Asperger syndrome
Letters to Editor
Mental disorders
Neuroses
Obsessive compulsive disorder
Psychotropic drugs
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Abstract AAPs are a common augmentative strategy in treatment-resistant OCD. [...]some have contended that dopamine blockade is critical to facilitate 5-hydroxytryptamine (5HT) transmission in the cortico-striato-pallido-thalamo-cortical neurocircuitry in OCD. [3] have found an incidence of 12% of AAPs-induced OCS in a cohort of schizophrenia and schizo-affective disorder (n = 209). Since 5HT dysregulation is central to OCD neurobiology, it seems that AAPs by virtue of 5HT2A antagonism might mechanistically induce these OCS as demonstrated by Zink. Dold M, Aigner M, Lanzenberger R, Kasper S. Antipsychotic augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: A meta-analysis of double-blind, randomized, placebo-controlled trials.
AbstractList AAPs are a common augmentative strategy in treatment-resistant OCD. [...]some have contended that dopamine blockade is critical to facilitate 5-hydroxytryptamine (5HT) transmission in the cortico-striato-pallido-thalamo-cortical neurocircuitry in OCD. [3] have found an incidence of 12% of AAPs-induced OCS in a cohort of schizophrenia and schizo-affective disorder (n = 209). Since 5HT dysregulation is central to OCD neurobiology, it seems that AAPs by virtue of 5HT2A antagonism might mechanistically induce these OCS as demonstrated by Zink. Dold M, Aigner M, Lanzenberger R, Kasper S. Antipsychotic augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: A meta-analysis of double-blind, randomized, placebo-controlled trials.
Audience Professional
Author Naguy, Ahmed
AuthorAffiliation Al-Manara CAP Centre, Kuwait Centre for Mental Health, Shuwaikh, Kuwait
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crossref_primary_10_1016_j_ajp_2018_04_025
crossref_primary_10_1016_j_ajp_2019_09_013
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Copyright 2017 Indian Psychiatric Society - South Zonal Branch
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Copyright Medknow Publications & Media Pvt. Ltd. Nov/Dec 2017
Copyright: © 2017 Indian Psychiatric Society 2017
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Snippet AAPs are a common augmentative strategy in treatment-resistant OCD. [...]some have contended that dopamine blockade is critical to facilitate...
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SubjectTerms Antidepressants
Antipsychotic agents
Antipsychotics
Asperger syndrome
Letters to Editor
Mental disorders
Neuroses
Obsessive compulsive disorder
Psychotropic drugs
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Title Antipsychotics and OCD: Boon or Bane?
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