Antipsychotics and OCD: Boon or Bane?

AAPs are a common augmentative strategy in treatment-resistant OCD. [...]some have contended that dopamine blockade is critical to facilitate 5-hydroxytryptamine (5HT) transmission in the cortico-striato-pallido-thalamo-cortical neurocircuitry in OCD. [3] have found an incidence of 12% of AAPs-induc...

Full description

Saved in:
Bibliographic Details
Published inIndian journal of psychological medicine Vol. 39; no. 6; pp. 830 - 831
Main Author Naguy, Ahmed
Format Journal Article
LanguageEnglish
Published New Delhi, India SAGE Publications 01.11.2017
Sage Publications Ltd. (UK)
Sage Publications, New Delhi India
Medknow Publications & Media Pvt Ltd
SAGE Publishing
Subjects
Antidepressants
Antipsychotic agents
Antipsychotics
Asperger syndrome
Letters to Editor
Mental disorders
Neuroses
Obsessive compulsive disorder
Psychotropic drugs
Online AccessGet full text

Cover

More Information
Summary:AAPs are a common augmentative strategy in treatment-resistant OCD. [...]some have contended that dopamine blockade is critical to facilitate 5-hydroxytryptamine (5HT) transmission in the cortico-striato-pallido-thalamo-cortical neurocircuitry in OCD. [3] have found an incidence of 12% of AAPs-induced OCS in a cohort of schizophrenia and schizo-affective disorder (n = 209). Since 5HT dysregulation is central to OCD neurobiology, it seems that AAPs by virtue of 5HT2A antagonism might mechanistically induce these OCS as demonstrated by Zink. Dold M, Aigner M, Lanzenberger R, Kasper S. Antipsychotic augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: A meta-analysis of double-blind, randomized, placebo-controlled trials.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0253-7176
0975-1564
DOI:10.4103/IJPSYM.IJPSYM_236_17