Effect of astaxanthin on cutaneous wound healing

Wound healing consists of a complex series of convoluted processes which involve renewal of the skin after injury. ROS are involved in all phases of wound healing. A balance between oxidative and antioxidative forces is necessary for a favorable healing outcome. Astaxanthin, a member of the xanthoph...

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Published inClinical, cosmetic and investigational dermatology Vol. 10; pp. 259 - 265
Main Authors Meephansan, Jitlada, Rungjang, Atiya, Yingmema, Werayut, Deenonpoe, Raksawan, Ponnikorn, Saranyoo
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2017
Taylor & Francis Ltd
Dove Medical Press
Subjects
Angiogenesis
antioxidant
Antioxidants
Astaxanthin
Biopsy
Blood clots
Carotenoids
Cell adhesion & migration
Cytokines
Dermatology
Enzyme regulation
Fibroblasts
Growth factors
Health aspects
Histopathology
Laboratory animals
Methods
Neutrophils
Original Research
Oxidative stress
Reactive oxygen species
Wound healing
Thailand
antioxidant
wound healing
reactive oxygen species
astaxanthin
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Summary:Wound healing consists of a complex series of convoluted processes which involve renewal of the skin after injury. ROS are involved in all phases of wound healing. A balance between oxidative and antioxidative forces is necessary for a favorable healing outcome. Astaxanthin, a member of the xanthophyll group, is considered a powerful antioxidant. In this study, we investigated the effect of topical astaxanthin on cutaneous wound healing. Full-thickness dermal wounds were created in 36 healthy female mice, which were divided into a control group and a group receiving 78.9 µM topical astaxanthin treatment twice daily for 15 days. Astaxanthin-treated wounds showed noticeable contraction by day 3 of treatment and complete wound closure by day 9, whereas the wounds of control mice revealed only partial epithelialization and still carried scabs. Wound healing biological markers including Col1A1 and bFGF were significantly increased in the astaxanthin-treated group since day 1. Interestingly, the oxidative stress marker iNOS showed a significantly lower expression in the study. The results indicate that astaxanthin is an effective compound for accelerating wound healing.
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ISSN:1178-7015
1178-7015
DOI:10.2147/ccid.s142795