Association of urinary bisphenol A with hyperlipidemia and all-cause mortality: NHANES 2003–2016

• Published in: PloS one Vol. 19; no. 7; p. e0304516
• Main Authors: Guo, Lijuan, Zhao, Pin, Xue, Shilong, Zhu, Zhaowei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2024; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Analysis; Benzhydryl Compounds - adverse effects; Benzhydryl Compounds - urine; Biology and Life Sciences; Bisphenol A; Body mass index; Diabetes; Ecology and Environmental Sciences; Female; Glucose; Health aspects; Health risks; High density lipoprotein; Humans; Hyperlipidemia; Hyperlipidemias - mortality; Hyperlipidemias - urine; Hypertension; Lipids; Male; Marital status; Medicine and Health Sciences; Metabolic disorders; Middle Aged; Mortality; Mortality risk; Nutrition Surveys; People and Places; Phenols; Phenols - urine; Physical Sciences; Population; Regression analysis; Risk; Smoking; Statistical analysis; Surveys; Urine; Variables; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0304516

The connection between urinary bisphenol A (BPA) and hyperlipidemia is still unclear, and few studies have evaluated whether urinary BPA affects mortality among individuals with hyperlipidemia. Therefore, we aimed to investigate the link between urinary BPA and hyperlipidemia and assess the impact of urinary BPA on mortality risk in subjects with hyperlipidemia. We analyzed data of the National Health and Nutrition Examination Survey from 2003 to 2016. Multivariable logistic analysis was performed to examine the relationship between urinary BPA and hyperlipidemia. Cox regression analysis was carried out to investigate the relationship between urinary BPA and all-cause mortality in subjects with hyperlipidemia. This study included 8,983 participants, of whom 6,317 (70.3%) were diagnosed with hyperlipidemia. The results showed that urinary BPA was higher in participants with hyperlipidemia group than those without hyperlipidemia (3.87 ± 0.32 vs. 2.98 ± 0.14, P = 0.01). Urinary BPA levels were analyzed in tertiles. Compared with tertile 1 of BPA (reference), the odds ratio (95% confidence interval) of hyperlipidemia related to tertile 3 of BPA was 1.28 (1.11-1.48). The hazard ratio for all-cause death associated with the highest versus lowest tertile of urinary BPA was 1.20 (95% confidence interval: 1.01-1.44; P = 0.04) among participants with hyperlipidemia. The study indicated a positive relationship between urinary BPA and the risk of hyperlipidemia. Urinary BPA was associated with a significantly higher risk of all-cause mortality in adults with hyperlipidemia.