Myelin/Oligodendrocyte Glycoprotein is a Member of a Subset of the Immunoglobulin Superfamily Encoded within the Major Histocompatibility Complex

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 90; no. 17; pp. 7990 - 7994
• Main Authors: Pham-Dinh, Danielle, Mattei, Marie-Genevieve, Nussbaum, Jean-Louis, Roussel, Guy, Pontarotti, Pierre, Roeckel, Nathalie, Mather, Ian H., Artzt, Karen, Lindahl, Kirsten Fischer, Dautigny, Andre
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01.09.1993; National Acad Sciences; National Academy of Sciences
• Subjects: 550400 - Genetics; Aging - metabolism; Amino Acid Sequence; Amino acids; Analytical, structural and metabolic biochemistry; ANIMALS; Base Sequence; BASIC BIOLOGICAL SCIENCES; Biological and medical sciences; Bleeding time; Brain - growth & development; Brain - metabolism; Cattle; CELL CONSTITUENTS; CELL MEMBRANES; Central nervous system; Chromosome Mapping; CHROMOSOMES; Chromosomes, Human, Pair 6; Complementary DNA; Deoxyribonucleic acid; DNA; Fundamental and applied biological sciences. Psychology; GENE MUTATIONS; Generally accepted auditing standards; GENES; Genes, Immunoglobulin; GENETIC MAPPING; GLYCOPROTEINS; Haplotypes - genetics; HUMAN CHROMOSOME 6; HUMAN CHROMOSOMES; Humans; In Situ Hybridization; Major Histocompatibility Complex - genetics; MAMMALS; MAPPING; Medical research; Membrane Glycoproteins - biosynthesis; Membrane Glycoproteins - genetics; MEMBRANES; Messenger RNA; MICE; Molecular Sequence Data; Multigene Family; MUTATIONS; MYELIN; Myelin Proteins; Myelin Sheath - metabolism; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Nerve Tissue Proteins - genetics; Nervous system; Oligodeoxyribonucleotides; ORGANIC COMPOUNDS; PROTEINS; Rats; RNA, Messenger - analysis; RNA, Messenger - metabolism; RODENTS; Sequence Homology, Amino Acid; Ungulates; VERTEBRATES; Cartography; Immunoglobulins; Myelin; Major histocompatibility system; Central nervous system; Primary structure; Glycoproteins; Lipoprotein; Gene expression; Vertebrata; Mammalia; Complementary DNA; Oligodendrocyte; Histocompatibility locus; Molecular cloning; Myelinization
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.90.17.7990

Myelin/oligodendrocyte glycoprotein (MOG) is found on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the central nervous system, and it is a target antigen in experimental autoimmune encephalomyelitis and multiple sclerosis. We have isolated bovine, mouse, and rat MOG cDNA clones and shown that the developmental pattern of MOG expression in the rat central nervous system coincides with the late stages of myelination. The amino-terminal, extracellular domain of MOG has characteristics of an immunoglobulin variable domain and is 46% and 41% identical with the amino terminus of bovine butyrophilin (expressed in the lactating mammary gland) and B-G antigens of the chicken major histocompatibility complex (MHC), respectively; these proteins thus form a subset of the immunoglobulin superfamily. The homology between MOG and B-G extends beyond their structure and genetic mapping to their ability to induce strong antibody responses and has implications for the role of MOG in pathological, autoimmune conditions. We colocalized the MOG and BT genes to the human MHC on chromosome 6p21.3-p22. The mouse MOG gene was mapped to the homologous band C of chromosome 17, within the M region of the mouse MHC.