Effectiveness of Combined Therapy with Pirfenidone and Erythromycin for Unclassifiable Interstitial Pneumonia Induced by HTLV-1-associated Bronchioloalveolar Disorder (HABA)

Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus involved in the pathogenesis of adult T-cell leukemia (ATL) and HTVL-1-associated bronchioloalveolar disorder (HABA). The clinical and pathological findings of HABA have been characterized as either a diffuse panbronchiolitis (DPB) patt...

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Published inInternal Medicine Vol. 56; no. 1; pp. 73 - 78
Main Authors Yokohori, Naoko, Sato, Akitoshi, Hasegawa, Mizue, Katsura, Hideki, Hiroshima, Kenzo, Takemura, Tamiko
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2017
Japan Science and Technology Agency
Subjects
Aged
Bronchial Diseases - diagnosis
Bronchiolitis - pathology
Case Report
Case reports
Corticoids
Corticosteroids
Drug Combinations
Erythromycin
Erythromycin - therapeutic use
Haemophilus Infections - pathology
HTLV-1-associated bronchioloalveolar disorder (HABA)
HTLV1-proviral pX gene
human T-cell lymphotropic virus type 1 (HTVL-1)
Human T-lymphotropic virus 1 - pathogenicity
Humans
Internal medicine
Leukemia
Leukemia-Lymphoma, Adult T-Cell - pathology
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - drug therapy
Lung Diseases, Interstitial - virology
Lymphocytes T
Male
Pathogenesis
pirfenidone
Pneumonia
Pyridones - therapeutic use
Retroviridae
unclassifiable interstitial pneumonia
Viruses
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Summary:Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus involved in the pathogenesis of adult T-cell leukemia (ATL) and HTVL-1-associated bronchioloalveolar disorder (HABA). The clinical and pathological findings of HABA have been characterized as either a diffuse panbronchiolitis (DPB) pattern or idiopathic interstitial pneumonia (IIP) pattern. Treatments for HABA include corticosteroids for the IIP pattern and erythromycin for the DPB pattern. We herein report a case of HABA-associated unclassifiable interstitial pneumonia that improved with combined therapy with pirfenidone and erythromycin. This is the first report on the effectiveness of combined therapy with pirfenidone and erythromycin for HABA.
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Correspondence to Dr.　Naoko Yokohori, wbycm409@ybb.ne.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.56.6995