Assessing the expression of immunosuppressive cytokines in the newly diagnosed systemic lupus Erythematosus patients: a focus on B cells

• Published in: BMC immunology Vol. 21; no. 1; pp. 58 - 12
• Main Authors: Abbasifard, Mitra, Kamiab, Zahra, Hasani, Mohammad, Rahnama, Amir, Saeed-Askari, Pooya, Khorramdelazad, Hossein
• Format: Journal Article
• Language: English
• Published: London BioMed Central 16.11.2020; BioMed Central Ltd; BMC
• Subjects: Adult; Allergology; Anti-Inflammatory Agents - metabolism; Anti-inflammatory cytokine; Antigens; Apoptosis; Autoimmune diseases; Autoimmunity; autoimmunity and vaccines; B-Lymphocytes, Regulatory - immunology; Biomedical and Life Sciences; Biomedicine; Care and treatment; Clinical immunology: transplants; Cytokines; Cytokines - genetics; Cytokines - metabolism; Cytokines and Growth Factors; Deoxyribonucleic acid; Development and progression; Disease; DNA; FasL protein; Female; Gene expression; Genes; Genetic aspects; Health aspects; Homeostasis; Humans; Immune response; Immune system; Immune Tolerance; Immunology; Immunosuppression; Inflammation; Interleukin 10; Lupus; Lupus Erythematosus, Systemic - immunology; Lymphocytes B; Male; Pathogenesis; Patients; PD-L1 protein; Regulatory B-cells (Bregs); Research Article; Serum levels; Systemic lupus erythematosus; Systemic lupus Erythematosus (SLE); Transforming growth factor-b; Vaccine; Young Adult; Iran; Systemic lupus Erythematosus (SLE); Anti-inflammatory cytokine; Regulatory B-cells (Bregs)
• ISSN: 1471-2172; 1471-2172
• DOI: 10.1186/s12865-020-00388-3

Background The immunosuppressive effects of regulatory B-cells (Bregs) and their immunosuppressive cytokines on immune responses in autoimmune disorders, mainly systemic lupus erythematosus (SLE), have been recently established. Therefore, the purpose of this article has been the exploration of the expressions of cytokines produced by B cells in newly diagnosed SLE patients. Results The findings demonstrated that the gene expression of IL-10, TGF-β, IL-35, PD-L1, and FasL was significantly up-regulated in SLE patients compared to healthy subjects ( P  < 0.05). Additionally, the results revealed that serum levels of IL-10, TGF-β, IL-35, PD-L1 were remarkably increased in patients with SLE compared to healthy subjects ( P  < 0.0001). However, serum levels of IL-10 and TGF-β decreased significantly with increasing SLEDAI score in studied patients ( P  < 0.05). Conclusion It was concluded that the release of anti-inflammatory cytokines, particularly IL-10 and TGF-β, might inhibit immune responses and autoreactive immune cells in a compensatory manner in SLE patients with mild to moderate disease activity.