BIOSYNTHESIS OF BENANOMICINS

The biosynthesis of benanomicins A and B, produced by actinomycete strain MH193-16F4, was investigated by feeding experiments with 14C- and 13C-labeled compounds followed by measurement of radioactivity and 13C NMR analysis. A 2D double quantum coherence NMR spectrum of benanomicin A derived from so...

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Bibliographic Details
Published inJournal of antibiotics Vol. 42; no. 7; pp. 1145 - 1150
Main Authors GOMI, SHUICHI, SEZAKI, MASAJI
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1989
Japan Antibiotics Research Association
Subjects
Actinomycetales - metabolism
actinomycetes
Anthracyclines
antibiotics
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antifungal Agents - biosynthesis
Applied microbiology
benanomicins
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Spectroscopy
Microbiology
Molecular Structure
Bacteria
Antibiotic
Antifungal agent
Actinomycetes
Biosynthesis
Molecular structure
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Summary:The biosynthesis of benanomicins A and B, produced by actinomycete strain MH193-16F4, was investigated by feeding experiments with 14C- and 13C-labeled compounds followed by measurement of radioactivity and 13C NMR analysis. A 2D double quantum coherence NMR spectrum of benanomicin A derived from sodium [1, 2-13C2]acetate provided the location of intact acetate units, and confirmed the 13C assignments of benanomicins. The results indicate that the aglycone of benanomicins is derived from a dodecaketide, methionine and alanine.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.42.1145