Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi

• Published in: Natural products and bioprospecting Vol. 10; no. 1; pp. 1 - 11
• Main Authors: Ye, Yan-Song, Wu, Man, Jiang, Na-Na, Lao, Yuan-Zhi, Fu, Wen-Wei, Liu, Xia, Yang, Xing-Wei, Zhang, Juan, Xu, Hong-Xi, Xu, Gang
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.02.2020; Springer Nature B.V; SpringerOpen
• Subjects: Anticancer properties; Apoptosis; Autophagy; Biomedical and Life Sciences; Bioorganic Chemistry; Cell cycle; Cell cycle arrest; Dearomatized isoprenylated acylphloroglucinols (DIAPs); Derivatives; Food Science; Hypericum; Hypericum henryi; Life Sciences; Lung cancer; Medicinal Chemistry; Metastases; NMR; Nuclear magnetic resonance; Original; Original Article; Parkin protein; Phagocytosis; Pharmacology/Toxicology; Plant Biochemistry; Plant Sciences; PTEN-induced putative kinase; Spectroscopy; Tumor cell lines; X-ray diffraction; Cell cycle arrest; Dearomatized isoprenylated acylphloroglucinols (DIAPs); Apoptosis; Hypericum henryi
• ISSN: 2192-2195; 2192-2209
• DOI: 10.1007/s13659-019-00229-w

A series of dearomatized isoprenylated acylphloroglucinols derivatives, hyperhenols A–E ( 1 – 5 ), as well as seven known analogues ( 6 – 12 ), were characterized from Hypericum henryi . Their structures were determined by combination of NMR, ECD spectroscopy, and X-ray diffraction analysis. Compounds 1 and 6 – 8 were tested to exhibit potential antitumor properties, of which 6 and 7 inhibited cell growth through inducing apoptosis and cell cycle arrest. In addition, these compounds could induce autophagy and PINK1/Parkin-mediated mitophagy in cancer cell lines, as well as suppress lung cancer A549 cells metastasis in vitro.