Interaction between the gut microbiome and mucosal immune system

The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturat...

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Published inMilitary medical research Vol. 4; no. 1; p. 14
Main Authors Shi, Na, Li, Na, Duan, Xinwang, Niu, Haitao
Format Journal Article
LanguageEnglish
Published England BioMed Central 27.04.2017
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences(CAMS)and Comparative Medicine Center, Peking Union Medical Collage(PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing 100021, China%Department of Rheumatology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China
BMC
Subjects
Bacteria
Digestive system
Gastrointestinal Microbiome - physiology
Homeostasis
Humans
Immune system
Immunity
Immunity, Innate - immunology
Immunity, Innate - physiology
Immunity, Mucosal - physiology
Inflammation
Intestines - immunology
Microbial Interactions - physiology
Microbiome
Microbiota
Microorganisms
Review
Small intestine
Studies
Immunity
Inflammation
Microbiome
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Summary:The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development. The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses, influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies.
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ISSN:2054-9369
2095-7467
2054-9369
DOI:10.1186/s40779-017-0122-9