PRODUCTION OF ENANTIOMER OF NANAOMYCIN A BY NOCARDIA

• Published in: Journal of antibiotics Vol. 42; no. 7; pp. 1186 - 1188
• Main Authors: IMAI, HARUMITSU, SUZUKI, KENICHI, KADOTA, SHIGENOBU, IWANAMI, MASARU, SAITO, TAKESHI
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1989; Japan Antibiotics Research Association
• Subjects: antibiotics; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antifungal Agents - biosynthesis; Antifungal Agents - isolation & purification; Applied microbiology; Biological and medical sciences; Chromatography, Thin Layer; Fermentation; Fundamental and applied biological sciences. Psychology; Microbiology; Molecular Structure; nanaomycin A; Naphthoquinones - biosynthesis; Naphthoquinones - isolation & purification; Nocardia - metabolism; quinone; Stereoisomerism; Actinomycetales; Antibiotic; Nocardia; Enantiomer; Bacteria; Nocardiaceae; Actinomycetes; Biosynthesis
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.42.1186

Nanaomycins (NNM's), kalafungin, OM-173 and frenolicins are members of a family of benzoisochromanquinone antibiotics. These antibiotics exhibit significant antimicrobial activities. Among these antibiotics, NNM-D and kalafungin are enantiomers with each other. The relationship of NNM-A and (+) NNM-A corresponds to that of NNM-D and kalafungin. NNM-A, NNM-D and kalafungin have been isolated from natural sources. (+) NNM-A has been prepared by enantiodivergent total syntheses but has not been reported as a natural product to date. The authors now report the isolation of (+) NNM-A from a fermentation broth of Nocardia species.