Alcohol Exposure Rate Control Through Physiologically Based Pharmacokinetic Modeling

• Published in: Alcoholism, clinical and experimental research Vol. 36; no. 6; pp. 1042 - 1049
• Main Authors: Plawecki, Martin H., Zimmermann, Ulrich S., Vitvitskiy, Victor, Doerschuk, Peter C., Crabb, David, O'Connor, Sean
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Blackwell Publishing Ltd 01.06.2012; Wiley
• Subjects: Acute Tolerance; Adult; Alcohol; Alcoholism and acute alcohol poisoning; Biological and medical sciences; Biphasic Effects; Brain - drug effects; Brain Exposure; Breath Tests - methods; Central Nervous System Depressants - pharmacokinetics; Ethanol - pharmacokinetics; Female; Humans; Infusions, Intravenous - methods; Male; Medical sciences; Models, Theoretical; Physiologically Based Pharmacokinetic Models; Rate of Change; Time Factors; Toxicology; Biphasic Effects; Ethanol; Acute; Rate of Change; Central nervous system; Tolerance; Alcohol; Exposure; Modeling; Encephalon; Alcoholic beverage; Physiologically Based Pharmacokinetic Models; Physiologically based pharmacokinetic model; Acute Tolerance; Brain Exposure

Background The instantaneous rate of change of alcohol exposure (slope) may contribute to changes in measures of brain function following administration of alcohol that are usually attributed to breath alcohol concentration (BrAC) acting alone. To test this proposition, a 2‐session experiment was de...