Remote Control of T Cell Activation Using Magnetic Janus Particles

• Published in: Angewandte Chemie International Edition Vol. 55; no. 26; pp. 7384 - 7387
• Main Authors: Lee, Kwahun, Yi, Yi, Yu, Yan
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 20.06.2016; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Activation analysis; Anisotropy; Atoms & subatomic particles; Cell activation; Cell recognition; colloids; Colloids - chemistry; Devices; immunology; Janus particles; Locomotion; Lymphocyte Activation; Lymphocytes; Lymphocytes T; Magnetic Fields; magnetic properties; Microparticles; Nanoparticles; nanotechnology; Orientation; Particle Size; Recognition; Remote control; Stimulation; T cell receptors; T-Lymphocytes - cytology; nanotechnology; magnetic properties; colloids; Janus particles; immunology

We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single‐cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the ro...