Remote Control of T Cell Activation Using Magnetic Janus Particles

We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single‐cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the ro...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 55; no. 26; pp. 7384 - 7387
Main Authors Lee, Kwahun, Yi, Yi, Yu, Yan
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 20.06.2016
Wiley Subscription Services, Inc
EditionInternational ed. in English
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Summary:We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single‐cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the rotation and locomotion of Janus particles under an external magnetic field, we could control the orientation of the particle–cell recognition and thereby the initiation of T cell activation. This study demonstrates a step towards employing anisotropic material properties of Janus particles to control single‐cell activities without the need of complex magnetic manipulation devices. Janus particles were employed to control T cell activation. The particles were magnetically responsive on one side and displayed ligands for T cell stimulation on the other side. T cell activation was remotely controlled by simultaneously manipulating the rotation and locomotion of the magnetic Janus particles.
Bibliography:ArticleID:ANIE201601211
istex:CAB206312CF5A685EDF284F09E8961093C9D0B4D
National Institutes of Health - No. UL1 TR001108
ark:/67375/WNG-8J102TV0-5
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201601211